Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)
1_MPGGG 6_ PEMDD 11_ YMETL 16_ KDEED 21_ ALWEN 26_ VECNR 31_ HMLSR 36_ YINPA 41_ KLTPY 46_ LRQCK 51_ VIDEQ 56_ DEDEV 61_ LNAPM 66_ LPSKI 71_ NRAGR 76_ LLDIL 81_ HTKGQ 86_ RGYVV 91_ FLESL 96_ EFYYP 101_ ELYKL 106_ VTGKE 111_ PTRRF 116_ STIVV 121_ EEGHE 126_ GLTHF 131_ LMNEV 136_ IKLQQ 141_ QMKAK 146_ DLQRC 151_ ELLAR 156_ LRQLE 161_ DEKKQ 166_ MTLTR 171_ VELLT 176_ FQERY 181_ YKMKE 186_ ERDSY 191_ NDELV 196_ KVKDD 201_ NYNLA 206_ MRYAQ 211_ LSEEK 216_ NMAVM 221_ RSRDL 226_ QLEID 231_ QLKHR 236_ LNKME 241_ EECKL 246_ ERNQS 251_ LKLKN 256_ DIENR 261_ PKKEQ 266_ VLELE 271_ RENEM 276_ LKTKN 281_ QELQS 286_ IIQAG 291_ KRSLP 296_ DSDKA 301_ ILDIL 306_ EHDRK 311_ EALED 316_ RQELV 321_ NRIYN 326_ LQEEA 331_ RQAEE 336_ LRDKY 341_ LEEKE 346_ DLELK 351_ CSTLG 356_ KDCEM 361_ YKHRM 366_ NTVML 371_ QLEEV 376_ ERERD 381_ QAFHS 386_ RDEAQ 391_ TQYSQ 396_ CLIEK 401_ DKYRK 406_ QIREL 411_ EEKND 416_ EMRIE 421_ MVRRE 426_ ACIVN 431_ LESKL 436_ RRLSK 441_ DSNNL 446_ DQSLP 451_ RNLPV 456_ TIISQ 461_ DFGDA 466_ SPRTN 471_ GQEAD 476_ DSSTS 481_ EESPE 486_ DSKYF 491_ LPYHP 496_ PQRRM 501_ NLKGI 506_ QLQRA 511_ KSPIS 516_ LKRTS 521_ DFQAK 526_ GHEEE 531_ GTDAS 536_ PSSCG 541_ SLPIT 546_ NSFTK 551_ MQPPR 556_ SRSSI 561_ MSITA 566_ EPPGN 571_ DSIVR 576_ RYKED 581_ APHRS 586_ TVEED 591_ NDSGG 596_ FDALD 601_ LDDDS 606_ HERYS 611_ FGPSS 616_ IHSSS 621_ SSHQS 626_ EGLDA 631_ YDLEQ 636_ VNLMF 641_ RKFSL 646_ ERPFR 651_ PSVTS 656_ VGHVR 661_ GPGPS 666_ VQHTT 671_ LNGDS 676_ LTSQL 681_ TLLGG 686_ NARGS 691_ FVHSV 696_ KPGSL 701_ AEKAG 706_ LREGH 711_ QLLLL 716_ EGCIR 721_ GERQS 726_ VPLDT 731_ CTKEE 736_ AHWTI 741_ QRCSG 746_ PVTLH 751_ YKVNH 756_ EGYRK 761_ LVKDM 766_ EDGLI 771_ TSGDS 776_ FYIRL 781_ NLNIS 786_ SQLDA 791_ CTMSL 796_ KCDDV 801_ VHVRD 806_ TMYQD 811_ RHEWL 816_ CARVD 821_ PFTDH 826_ DLDMG 831_ TIPSY 836_ SRAQQ 841_ LLLVK 846_ LQRLM 851_ HRGSR 856_ EEVDG 861_ THHTL 866_ RALRN 871_ TLQPE 876_ EALST 881_ SDPRV 886_ SPRLS 891_ RASFL 896_ FGQLL 901_ QFVSR 906_ SENKY 911_ KRMNS 916_ NERVR 921_ IISGS 926_ PLGSL 931_ ARSSL 936_ DATKL 941_ LTEKQ 946_ EELDP 951_ ESELG 956_ KNLSL 961_ IPYSL 966_ VRAFY 971_ CERRR 976_ PVLFT 981_ PTVLA 986_ KTLVQ 991_ RLLNS 996_ GGAME 1001_ FTICK 1006_ SDIVT 1011_ RDEFL 1016_ RRQKT 1021_ ETIIY 1026_ SREKN 1031_ PNAFE 1036_ CIAPA 1041_ NIEAV 1046_ AAKNK 1051_ HCLLE 1056_ AGIGC 1061_ TRDLI 1066_ KSNIY 1071_ PIVLF 1076_ IRVCE 1081_ KNIKR 1086_ FRKLL 1091_ PRPET 1096_ EEEFL 1101_ RVCRL 1106_ KEKEL 1111_ EALPC 1116_ LYATV 1121_ EPDMW 1126_ GSVEE 1131_ LLRVV 1136_ KDKIG 1141_ EEQRK 1146_TIWVD
1: Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108)