Asporin (Periodontal ligament-associated protein 1) (PLAP-1)
1_MKEYV 6_ LLLFL 11_ ALCSA 16_ KPFFS 21_ PSHIA 26_ LKNMM 31_ LKDME 36_ DTDDD 41_ DDDDD 46_ DDDDD 51_ DEDNS 56_ LFPTR 61_ EPRSH 66_ FFPFD 71_ LFPMC 76_ PFGCQ 81_ CYSRV 86_ VHCSD 91_ LGLTS 96_ VPTNI 101_ PFDTR 106_ MLDLQ 111_ NNKIK 116_ EIKEN 121_ DFKGL 126_ TSLYG 131_ LILNN 136_ NKLTK 141_ IHPKA 146_ FLTTK 151_ KLRRL 156_ YLSHN 161_ QLSEI 166_ PLNLP 171_ KSLAE 176_ LRIHE 181_ NKVKK 186_ IQKDT 191_ FKGMN 196_ ALHVL 201_ EMSAN 206_ PLDNN 211_ GIEPG 216_ AFEGV 221_ TVFHI 226_ RIAEA 231_ KLTSV 236_ PKGLP 241_ PTLLE 246_ LHLDY 251_ NKIST 256_ VELED 261_ FKRYK 266_ ELQRL 271_ GLGNN 276_ KITDI 281_ ENGSL 286_ ANIPR 291_ VREIH 296_ LENNK 301_ LKKIP 306_ SGLPE 311_ LKYLQ 316_ IIFLH 321_ SNSIA 326_ RVGVN 331_ DFCPT 336_ VPKMK 341_ KSLYS 346_ AISLF 351_ NNPVK 356_ YWEMQ 361_ PATFR 366_ CVLSR 371_MSVQL
1: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity