Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)
1_MGDSD 6_ DEYDR 11_ RRRDK 16_ FRRER 21_ SDYDR 26_ SRERD 31_ ERRRG 36_ DDWND 41_ REWDR 46_ GRERR 51_ SRGEY 56_ RDYDR 61_ NRRER 66_ FSPPR 71_ HELSP 76_ PQKRM 81_ RRDWD 86_ EHSSD 91_ PYHSG 96_ YEMPY 101_ AGGGG 106_ GPTYG 111_ PPQPW 116_ GHPDV 121_ HIMQH 126_ HVLPI 131_ QARLG 136_ SIAEI 141_ DLGVP 146_ PPVMK 151_ TFKEF 156_ LLSLD 161_ DSVDE 166_ TEAVK 171_ RYNDY 176_ KLDFR 181_ RQQMQ 186_ DFFLA 191_ HKDEE 196_ WFRSK 201_ YHPDE 206_ VGKRR 211_ QEARG 216_ ALQNR 221_ LRVFL 226_ SLMET 231_ GWFDN 236_ LLLDI 241_ DKADA 246_ IVKML 251_ DAAVI 256_ KMEGG 261_ TENDL 266_ RILEQ 271_ EEEEE 276_ QAGKP 281_ GEPSK 286_ KEEGR 291_ AGAGL 296_ GDGER 301_ KTNDK 306_ DEKKE 311_ DGKQA 316_ ENDSS 321_ NDDKT 326_ KKSEG 331_ DGDKE 336_ EKKED 341_ SEKEA 346_ KKSSK 351_ KRNRK 356_ HSGDD 361_ SFDEG 366_ SVSES 371_ ESESE 376_ SGQAE 381_ EEKEE 386_ AEEAL 391_ KEKEK 396_ PKEEE 401_ WEKPK 406_ DAAGL 411_ ECKPR 416_ PLHKT 421_ CSLFM 426_ RNIAP 431_ NISRA 436_ EIISL 441_ CKRYP 446_ GFMRV 451_ ALSEP 456_ QPERR 461_ FFRRG 466_ WVTFD 471_ RSVNI 476_ KEICW 481_ NLQNI 486_ RLREC 491_ ELSPG 496_ VNRDL 501_ TRRVR 506_ NINGI 511_ TQHKQ 516_ IVRND 521_ IKLAA 526_ KLIHT 531_ LDDRT 536_ QLWAS 541_ EPGTP 546_ PLPTS 551_ LPSQN 556_ PILKN 561_ ITDYL 566_ IEEVS 571_ AEEEE 576_ LLGSS 581_ GGAPP 586_ EEPPK 591_ EGNPA 596_ EINVE 601_ RDEKL 606_ IKVLD 611_ KLLLY 616_ LRIVH 621_ SLDYY 626_ NTCEY 631_ PNEDE 636_ MPNRC 641_ GIIHV 646_ RGPMP 651_ PNRIS 656_ HGEVL 661_ EWQKT 666_ FEEKL 671_ TPLLS 676_ VRESL 681_ SEEEA 686_ QKMGR 691_ KDPEQ 696_ EVEKF 701_ VTSNT 706_ QELGK 711_ DKWLC 716_ PLSGK 721_ KFKGP 726_ EFVRK 731_ HIFNK 736_ HAEKI 741_ EEVKK 746_ EVAFF 751_ NNFLT 756_ DAKRP 761_ ALPEI 766_ KPAQP 771_ PGPAQ 776_ ILPPG 781_ LTPGL 786_ PYPHQ 791_ TPQGL 796_ MPYGQ 801_ PRPPI 806_ LGYGA 811_ GAVRP 816_ AVPTG 821_ GPPYP 826_ HAPYG 831_ AGRGN 836_ YDAFR 841_ GQGGY 846_ PGKPR 851_ NRMVR 856_ GDPRA 861_ IVEYR 866_ DLDAP 871_DDVDF
1: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity)