Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E)
1_MMCLK 6_ ILRIS 11_ LAILA 16_ GWALC 21_ SANSE 26_ LGWTR 31_ KKSLV 36_ EREHL 41_ NQVLL 46_ EGERC 51_ WLGAK 56_ VRRPR 61_ ASPQH 66_ HLFGV 71_ YPSRA 76_ GNYLR 81_ PYPVG 86_ EQEIH 91_ HTGRS 96_ KPDTE 101_ GNAVS 106_ LVPPD 111_ LTENP 116_ AGLRG 121_ AVEEP 126_ AAPWV 131_ GDSPI 136_ GQSEL 141_ LGDDD 146_ AYLGN 151_ QRSKE 156_ SLGEA 161_ GIQKG 166_ SAMAA 171_ TTTTA 176_ IFTTL 181_ NEPKP 186_ ETQRR 191_ GWAKS 196_ RQRRQ 201_ VWKRR 206_ AEDGQ 211_ GDSGI 216_ SSHFQ 221_ PWPKH 226_ SLKHR 231_ VKKSP 236_ PEESN 241_ QNGGE 246_ GSYRE 251_ AETFN 256_ SQVGL 261_ PILYF 266_ SGRRE 271_ RLLLR 276_ PEVLA 281_ EIPRE 286_ AFTVE 291_ AWVKP 296_ EGGQN 301_ NPAII 306_ AGVFD 311_ NCSHT 316_ VSDKG 321_ WALGI 326_ RSGKD 331_ KGKRD 336_ ARFFF 341_ SLCTD 346_ RVKKA 351_ TILIS 356_ HSRYQ 361_ PGTWT 366_ HVAAT 371_ YDGRH 376_ MALYV 381_ DGTQV 386_ ASSLD 391_ QSGPL 396_ NSPFM 401_ ASCRS 406_ LLLGG 411_ DSSED 416_ GHYFR 421_ GHLGT 426_ LVFWS 431_ TALPQ 436_ SHFQH 441_ SSQHS 446_ SGEEE 451_ ATDLV 456_ LTASF 461_ EPVNT 466_ EWVPF 471_ RDEKY 476_ PRLEV 481_ LQGFE 486_ PEPEI 491_ LSPLQ 496_ PPLCG 501_ QTVCD 506_ NVELI 511_ SQYNG 516_ YWPLR 521_ GEKVI 526_ RYQVV 531_ NICDD 536_ EGLNP 541_ IVSEE 546_ QIRLQ 551_ HEALN 556_ EAFSR 561_ YNISW 566_ QLSVH 571_ QVHNS 576_ TLRHR 581_ VVLVN 586_ CEPSK 591_ IGNDH 596_ CDPEC 601_ EHPLT 606_ GYDGG 611_ DCRLQ 616_ GRCYS 621_ WNRRD 626_ GLCHV 631_ ECNNM 636_ LNDFD 641_ DGDCC 646_ DPQVA 651_ DVRKT 656_ CFDPD 661_ SPKRA 666_ YMSVK 671_ ELKEA 676_ LQLNS 681_ THFLN 686_ IYFAS 691_ SVRED 696_ LAGAA 701_ TWPWD 706_ KDAVT 711_ HLGGI 716_ VLSPA 721_ YYGMP 726_ GHTDT 731_ MIHEV 736_ GHVLG 741_ LYHVF 746_ KGVSE 751_ RESCN 756_ DPCKE 761_ TVPSM 766_ ETGDL 771_ CADTA 776_ PTPKS 781_ ELCRE 786_ PEPTS 791_ DTCGF 796_ TRFPG 801_ APFTN 806_ YMSYT 811_ DDNCT 816_ DNFTP 821_ NQVAR 826_ MHCYL 831_ DLVYQ 836_ QWTES 841_ RKPTP 846_ IPIPP 851_ MVIGQ 856_ TNKSL 861_ TIHWL 866_ PPISG 871_ VVYDR 876_ ASGSL 881_ CGACT 886_ EDGTF 891_ RQYVH 896_ TASSR 901_ RVCDS 906_ SGYWT 911_ PEEAV 916_ GPPDV 921_ DQPCE 926_ PSLQA 931_ WSPEV 936_ HLYHM 941_ NMTVP 946_ CPTEG 951_ CSLEL 956_ LFQHP 961_ VQADT 966_ LTLWV 971_ TSFFM 976_ ESSQV 981_ LFDTE 986_ ILLEN 991_ KESVH 996_ LGPLD 1001_ TFCDI 1006_ PLTIK 1011_ LHVDG 1016_ KVSGV 1021_ KVYTF 1026_ DERIE 1031_ IDAAL 1036_ LTSQP 1041_ HSPLC 1046_ SGCRP 1051_ VRYQV 1056_ LRDPP 1061_ FASGL 1066_ PVVVT 1071_ HSHRK 1076_ FTDVE 1081_ VTPGQ 1086_ MYQYQ 1091_ VLAEA 1096_ GGELG 1101_ EASPP 1106_ LNHIH 1111_ GAPYC 1116_ GDGKV 1121_ SERLG 1126_ EECDD 1131_ GDLVS 1136_ GDGCS 1141_ KVCEL 1146_ EEGFN 1151_ CVGEP 1156_ SLCYM 1161_ YEGDG 1166_ ICEPF 1171_ ERKTS 1176_ IVDCG 1181_ IYTPK 1186_ GYLDQ 1191_ WATRA 1196_ YSSHE 1201_ DKKKC 1206_ PVSLV 1211_ TGEPH 1216_ SLICT 1221_ SYHPD 1226_ LPNHR 1231_ PLTGW 1236_ FPCVA 1241_ SENET 1246_ QDDRS 1251_ EQPEG 1256_ SLKKE 1261_ DEVWL 1266_ KVCFN 1271_ RPGEA 1276_ RAIFI 1281_ FLTTD 1286_ GLVPG 1291_ EHQQP 1296_ TVTLY 1301_ LTDVR 1306_ GSNHS 1311_ LGTYG 1316_ LSCQH 1321_ NPLII 1326_ NVTHH 1331_ QNVLF 1336_ HHTTS 1341_ VLLNF 1346_ SSPRV 1351_ GISAV 1356_ ALRTS 1361_ SRIGL 1366_ SAPSN 1371_ CISED 1376_ EGQNH 1381_ QGQSC 1386_ IHRPC 1391_ GKQDS 1396_ CPSLL 1401_ LDHAD 1406_ VVNCT 1411_ SIGPG 1416_ LMKCA 1421_ ITCQR 1426_ GFALQ 1431_ ASSGQ 1436_ YIRPM 1441_ QKEIL 1446_ LTCSS 1451_ GHWDQ 1456_ NVSCL 1461_ PVDCG 1466_ VPDPS 1471_ LVNYA 1476_ NFSCS 1481_ EGTKF 1486_ LKRCS 1491_ ISCVP 1496_ PAKLQ 1501_ GLSPW 1506_ LTCLE 1511_ DGLWS 1516_ LPEVY 1521_ CKLEC 1526_ DAPPI 1531_ ILNAN 1536_ LLLPH 1541_ CLQDN 1546_ HDVGT 1551_ ICKYE 1556_ CKPGY 1561_ YVAES 1566_ AEGKV 1571_ RNKLL 1576_ KIQCL 1581_ EGGIW 1586_ EQGSC 1591_ IPVVC 1596_ EPPPP 1601_ VFEGM 1606_ YECTN 1611_ GFSLD 1616_ SQCVL 1621_ NCNQE 1626_ REKLP 1631_ ILCTK 1636_ EGLWT 1641_ QEFKL 1646_ CENLQ 1651_ GECPP 1656_ PPSEL 1661_ NSVEY 1666_ KCEQG 1671_ YGIGA 1676_ VCSPL 1681_ CVIPP 1686_ SDPVM 1691_ LPENI 1696_ TADTL 1701_ EHWME 1706_ PVKVQ 1711_ SIVCT 1716_ GRRQW 1721_ HPDPV 1726_ LVHCI 1731_ QSCEP 1736_ FQADG 1741_ WCDTI 1746_ NNRAY 1751_ CHYDG 1756_ GDCCS 1761_ STLSS 1766_ KKVIP 1771_ FAADC 1776_ DLDEC 1781_ TCRDP 1786_KAEEN
1: Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3