Transmembrane protein 59 (Liver membrane-bound protein)
1_MAAPK 6_ GSLWV 11_ RTQLG 16_ LPPLL 21_ LLTMA 26_ LAGGS 31_ GTASA 36_ EAFDS 41_ VLGDT 46_ ASCHR 51_ ACQLT 56_ YPLHT 61_ YPKEE 66_ ELYAC 71_ QRGCR 76_ LFSIC 81_ QFVDD 86_ GIDLN 91_ RTKLE 96_ CESAC 101_ TEAYS 106_ QSDEQ 111_ YACHL 116_ GCQNQ 121_ LPFAE 126_ LRQEQ 131_ LMSLM 136_ PKMHL 141_ LFPLT 146_ LVRSF 151_ WSDMM 156_ DSAQS 161_ FITSS 166_ WTFYL 171_ QADDG 176_ KIVIF 181_ QSKPE 186_ IQYAP 191_ HLEQE 196_ PTNLR 201_ ESSLS 206_ KMSYL 211_ QMRNS 216_ QAHRN 221_ FLEDG 226_ ESDGF 231_ LRCLS 236_ LNSGW 241_ ILTTT 246_ LVLSV 251_ MVLLW 256_ ICCAT 261_ VATAV 266_ EQYVP 271_ SEKLS 276_ IYGDL 281_ EFMNE 286_ QKLNR 291_ YPASS 296_ LVVVR 301_ SKTED 306_ HEEAG 311_ PLPTK 316_VNLAH
1: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:23376921, PubMed:27273576). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278)