Fanconi anemia group D2 protein (Protein FACD2)
1_MVSKR 6_ RLSKS 11_ EDKES 16_ LTEDA 21_ SKTRK 26_ QPLSK 31_ KTKKS 36_ HIANE 41_ VEEND 46_ SIFVK 51_ LLKIS 56_ GIILK 61_ TGESQ 66_ NQLAV 71_ DQIAF 76_ QKKLF 81_ QTLRR 86_ HPSYP 91_ KIIEE 96_ FVSGL 101_ ESYIE 106_ DEDSF 111_ RNCLL 116_ SCERL 121_ QDEEA 126_ SMGAS 131_ YSKSL 136_ IKLLL 141_ GIDIL 146_ QPAII 151_ KTLFE 156_ KLPEY 161_ FFENK 166_ NSDEI 171_ NIPRL 176_ IVSQL 181_ KWLDR 186_ VVDGK 191_ DLTTK 196_ IMQLI 201_ SIAPE 206_ NLQHD 211_ IITSL 216_ PEILG 221_ DSQHA 226_ DVGKE 231_ LSDLL 236_ IENTS 241_ LTVPI 246_ LDVLS 251_ SLRLD 256_ PNFLL 261_ KVRQL 266_ VMDKL 271_ SSIRL 276_ EDLPV 281_ IIKFI 286_ LHSVT 291_ AMDTL 296_ EVISE 301_ LREKL 306_ DLQHC 311_ VLPSR 316_ LQASQ 321_ VKLKS 326_ KGRAS 331_ SSGNQ 336_ ESSGQ 341_ SCIIL 346_ LFDVI 351_ KSAIR 356_ YEKTI 361_ SEAWI 366_ KAIEN 371_ TASVS 376_ EHKVF 381_ DLVML 386_ FIIYS 391_ TNTQT 396_ KKYID 401_ RVLRN 406_ KIRSG 411_ CIQEQ 416_ LLQST 421_ FSVHY 426_ LVLKD 431_ MCSSI 436_ LSLAQ 441_ SLLHS 446_ LDQSI 451_ ISFGS 456_ LLYKY 461_ AFKFF 466_ DTYCQ 471_ QEVVG 476_ ALVTH 481_ ICSGN 486_ EAEVD 491_ TALDV 496_ LLELV 501_ VLNPS 506_ AMMMN 511_ AVFVK 516_ GILDY 521_ LDNIS 526_ PQQIR 531_ KLFYV 536_ LSTLA 541_ FSKQN 546_ EASSH 551_ IQDDM 556_ HLVIR 561_ KQLSS 566_ TVFKY 571_ KLIGI 576_ IGAVT 581_ MAGIM 586_ AADRS 591_ ESPSL 596_ TQERA 601_ NLSDE 606_ QCTQV 611_ TSLLQ 616_ LVHSC 621_ SEQSP 626_ QASAL 631_ YYDEF 636_ ANLIQ 641_ HEKLD 646_ PKALE 651_ WVGHT 656_ ICNDF 661_ QDAFV 666_ VDSCV 671_ VPEGD 676_ FPFPV 681_ KALYG 686_ LEEYD 691_ TQDGI 696_ AINLL 701_ PLLFS 706_ QDFAK 711_ DGGPV 716_ TSQES 721_ GQKLV 726_ SPLCL 731_ APYFR 736_ LLRLC 741_ VERQH 746_ NGNLE 751_ EIDGL 756_ LDCPI 761_ FLTDL 766_ EPGEK 771_ LESMS 776_ AKERS 781_ FMCSL 786_ IFLTL 791_ NWFRE 796_ IVNAF 801_ CQETS 806_ PEMKG 811_ KVLTR 816_ LKHIV 821_ ELQII 826_ LEKYL 831_ AVTPD 836_ YVPPL 841_ GNFDV 846_ ETLDI 851_ TPHTV 856_ TAISA 861_ KIRKK 866_ GKIER 871_ KQKTD 876_ GSKTS 881_ SSDTL 886_ SEEKN 891_ SECDP 896_ TPSHR 901_ GQLNK 906_ EFTGK 911_ EEKTS 916_ LLLHN 921_ SHAFF 926_ RELDI 931_ EVFSI 936_ LHCGL 941_ VTKFI 946_ LDTEM 951_ HTEAT 956_ EVVQL 961_ GPPEL 966_ LFLLE 971_ DLSQK 976_ LESML 981_ TPPIA 986_ RRVPF 991_ LKNKG 996_ SRNIG 1001_ FSHLQ 1006_ QRSAQ 1011_ EIVHC 1016_ VFQLL 1021_ TPMCN 1026_ HLENI 1031_ HNYFQ 1036_ CLAAE 1041_ NHGVV 1046_ DGPGV 1051_ KVQEY 1056_ HIMSS 1061_ CYQRL 1066_ LQIFH 1071_ GLFAW 1076_ SGFSQ 1081_ PENQN 1086_ LLYSA 1091_ LHVLS 1096_ SRLKQ 1101_ GEHSQ 1106_ PLEEL 1111_ LSQSV 1116_ HYLQN 1121_ FHQSI 1126_ PSFQC 1131_ ALYLI 1136_ RLLMV 1141_ ILEKS 1146_ TASAQ 1151_ NKEKI 1156_ ASLAR 1161_ QFLCR 1166_ VWPSG 1171_ DKEKS 1176_ NISND 1181_ QLHAL 1186_ LCIYL 1191_ EHTES 1196_ ILKAI 1201_ EEIAG 1206_ VGVPE 1211_ LINSP 1216_ KDASS 1221_ STFPT 1226_ LTRHT 1231_ FVVFF 1236_ RVMMA 1241_ ELEKT 1246_ VKKIE 1251_ PGTAA 1256_ DSQQI 1261_ HEEKL 1266_ LYWNM 1271_ AVRDF 1276_ SILIN 1281_ LIKVF 1286_ DSHPV 1291_ LHVCL 1296_ KYGRL 1301_ FVEAF 1306_ LKQCM 1311_ PLLDF 1316_ SFRKH 1321_ REDVL 1326_ SLLET 1331_ FQLDT 1336_ RLLHH 1341_ LCGHS 1346_ KIHQD 1351_ TRLTQ 1356_ HVPLL 1361_ KKTLE 1366_ LLVCR 1371_ VKAML 1376_ TLNNC 1381_ REAFW 1386_ LGNLK 1391_ NRDLQ 1396_ GEEIK 1401_ SQNSQ 1406_ ESTAD 1411_ ESEDD 1416_ MSSQA 1421_ SKSKA 1426_ TEDGE 1431_ EDEVS 1436_ AGEKE 1441_ QDSDE 1446_SYDDS
1: Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching