Protein BEX2 (Brain-expressed X-linked protein 2) (hBex2)
1_MESKE 6_ ERALN 11_ NLIVE 16_ NVNQE 21_ NDEKD 26_ EKEQV 31_ ANKGE 36_ PLALP 41_ LNVSE 46_ YCVPR 51_ GNRRR 56_ FRVRQ 61_ PILQY 66_ RWDIM 71_ HRLGE 76_ PQARM 81_ REENM 86_ ERIGE 91_ EVRQL 96_ MEKLR 101_ EKQLS 106_ HSLRA 111_ VSTDP 116_ PHHDH 121_HDEFC
1: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer (PubMed:19711341). Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA (PubMed:19711341). Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A (PubMed:19711341). Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (PubMed:19711341). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)