Thymic stromal cotransporter homolog (Solute carrier family 46 member 2)
1_MSPEV 6_ TCPRR 11_ GHLPR 16_ FHPRT 21_ WVEPV 26_ VASSQ 31_ VAASL 36_ YDAGL 41_ LLVVK 46_ ASYGT 51_ GGSSN 56_ HSASP 61_ SPRGA 66_ LEDQQ 71_ QRAIS 76_ NFYII 81_ YNLVV 86_ GLSPL 91_ LSAYG 96_ LGWLS 101_ DRYHR 106_ KISIC 111_ MSLLG 116_ FLLSR 121_ LGLLL 126_ KVLLD 131_ WPVEV 136_ LYGAA 141_ ALNGL 146_ FGGFS 151_ AFWSG 156_ VMALG 161_ SLGSS 166_ EGRRS 171_ VRLIL 176_ IDLML 181_ GLAGF 186_ CGSMA 191_ SGHLF 196_ KQMAG 201_ HSGQG 206_ LILTA 211_ CSVSC 216_ ASFAL 221_ LYSLL 226_ VLKVP 231_ ESVAK 236_ PSQEL 241_ PAVDT 246_ VSGTV 251_ GTYRT 256_ LDPDQ 261_ LDQQY 266_ AVGHP 271_ PSPGK 276_ AKPHK 281_ TTIAL 286_ LFVGA 291_ IIYDL 296_ AVVGT 301_ VDVIP 306_ LFVLR 311_ EPLGW 316_ NQVQV 321_ GYGMA 326_ AGYTI 331_ FITSF 336_ LGVLV 341_ FSRCF 346_ RDTTM 351_ IMIGM 356_ VSFGS 361_ GALLL 366_ AFVKE 371_ TYMFY 376_ IARAV 381_ MLFAL 386_ IPVTT 391_ IRSAM 396_ SKLIK 401_ GSSYG 406_ KVFVI 411_ LQLSL 416_ ALTGV 421_ VTSTL 426_ YNKIY 431_ QLTMD 436_ MFVGS 441_ CFALS 446_ SFLSF 451_ LAIIP 456_ ISIVA 461_ YKQVP 466_LSPYG
1: Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury (PubMed:28539433, PubMed:34235268). Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88-dependent secretion of IL1A and neutrophil recruitment in a pyroptosis-type inflammatory process (PubMed:28539433). To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses (PubMed:28539433). Postulated to function as a dominant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor-derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable)