Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)
1_MSSSY 6_ DEASL 11_ APEET 16_ TDSFW 21_ EVGNY 26_ KRTVK 31_ RIDDG 36_ HRLCN 41_ DLMNC 46_ VQERA 51_ KIEKA 56_ YGQQL 61_ TDWAK 66_ RWRQL 71_ IEKGP 76_ QYGSL 81_ ERAWG 86_ AIMTE 91_ ADKVS 96_ ELHQE 101_ VKNNL 106_ LNEDL 111_ EKVKN 116_ WQKDA 121_ YHKQI 126_ MGGFK 131_ ETKEA 136_ EDGFR 141_ KAQKP 146_ WAKKM 151_ KELEA 156_ AKKAY 161_ HLACK 166_ EEKLA 171_ MTREM 176_ NSKTE 181_ QSVTP 186_ EQQKK 191_ LQDKV 196_ DKCKQ 201_ DVQKT 206_ QEKYE 211_ KVLED 216_ VGKTT 221_ PQYME 226_ NMEQV 231_ FEQCQ 236_ QFEEK 241_ RLVFL 246_ KEVLL 251_ DIKRH 256_ LNLAE 261_ NSSYI 266_ HVYRE 271_ LEQAI 276_ RGADA 281_ QEDLR 286_ WFRST 291_ SGPGM 296_ PMNWP 301_ QFEEW 306_ NPDLP 311_ HTTTK 316_ KEKQP 321_ KKAEG 326_ VALTN 331_ ATGAV 336_ ESTSQ 341_ AGDRG 346_ SVSSY 351_ DRGQP 356_ YATEW 361_ SDDES 366_ GNPFG 371_ GSETN 376_ GGANP 381_ FEDDS 386_ KGVRV 391_ RALYD 396_ YDGQE 401_ QDELS 406_ FKAGD 411_ ELTKL 416_ GEEDE 421_ QGWCR 426_ GRLDS 431_ GQLGL 436_YPANY
1: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation