Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p)
1_MAASL 6_ VGKKI 11_ VFVTG 16_ NAKKL 21_ EEVVQ 26_ ILGDK 31_ FPCTL 36_ VAQKI 41_ DLPEY 46_ QGEPD 51_ EISIQ 56_ KCQEA 61_ VRQVQ 66_ GPVLV 71_ EDTCL 76_ CFNAL 81_ GGLPG 86_ PYIKW 91_ FLEKL 96_ KPEGL 101_ HQLLA 106_ GFEDK 111_ SAYAL 116_ CTFAL 121_ STGDP 126_ SQPVR 131_ LFRGR 136_ TSGRI 141_ VAPRG 146_ CQDFG 151_ WDPCF 156_ QPDGY 161_ EQTYA 166_ EMPKA 171_ EKNAV 176_ SHRFR 181_ ALLEL 186_QEYFG
1: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions