Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-)
1_MEEPE 6_ EPADS 11_ GQSLV 16_ PVYIY 21_ SPEYV 26_ SMCDS 31_ LAKIP 36_ KRASM 41_ VHSLI 46_ EAYAL 51_ HKQMR 56_ IVKPK 61_ VASME 66_ EMATF 71_ HTDAY 76_ LQHLQ 81_ KVSQE 86_ GDDDH 91_ PDSIE 96_ YGLGY 101_ DCPAT 106_ EGIFD 111_ YAAAI 116_ GGATI 121_ TAAQC 126_ LIDGM 131_ CKVAI 136_ NWSGG 141_ WHHAK 146_ KDEAS 151_ GFCYL 156_ NDAVL 161_ GILRL 166_ RRKFE 171_ RILYV 176_ DLDLH 181_ HGDGV 186_ EDAFS 191_ FTSKV 196_ MTVSL 201_ HKFSP 206_ GFFPG 211_ TGDVS 216_ DVGLG 221_ KGRYY 226_ SVNVP 231_ IQDGI 236_ QDEKY 241_ YQICE 246_ SVLKE 251_ VYQAF 256_ NPKAV 261_ VLQLG 266_ ADTIA 271_ GDPMC 276_ SFNMT 281_ PVGIG 286_ KCLKY 291_ ILQWQ 296_ LATLI 301_ LGGGG 306_ YNLAN 311_ TARCW 316_ TYLTG 321_ VILGK 326_ TLSSE 331_ IPDHE 336_ FFTAY 341_ GPDYV 346_ LEITP 351_ SCRPD 356_ RNEPH 361_ RIQQI 366_ LNYIK 371_GNLKH
1: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin (PubMed:22885700). May play a role in smooth muscle cell contractility (PubMed:15772115). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810)