Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1)
1_MGCDG 6_ GTIPK 11_ RHELV 16_ KGPKK 21_ VEKVD 26_ KDAEL 31_ VAQWN 36_ YCTLS 41_ QEILR 46_ RPIVA 51_ CELGR 56_ LYNKD 61_ AVIEF 66_ LLDKS 71_ AEKAL 76_ GKAAS 81_ HIKSI 86_ KNVTE 91_ LKLSD 96_ NPAWE 101_ GDKGN 106_ TKGDK 111_ HDDLQ 116_ RARFI 121_ CPVVG 126_ LEMNG 131_ RHRFC 136_ FLRCC 141_ GCVFS 146_ ERALK 151_ EIKAE 156_ VCHTC 161_ GAAFQ 166_ EDDVI 171_ MLNGT 176_ KEDVD 181_ VLKTR 186_ MEERR 191_ LRAKL 196_ EKKTK 201_ KPKAA 206_ ESVSK 211_ PDVSE 216_ EAPGP 221_ SKVKT 226_ GKPEE 231_ ASLDS 236_ REKKT 241_ NLAPK 246_ STAMN 251_ ESSSG 256_ KAGKP 261_ PCGAT 266_ KRSIA 271_ DSEES 276_ EAYKS 281_ LFTTH 286_ SSAKR 291_ SKEES 296_ AHWVT 301_HTSYC
1: Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612)