Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21)
1_MVRAG 6_ AVGAH 11_ LPASG 16_ LDIFG 21_ DLKKM 26_ NKRQL 31_ YYQVL 36_ NFAMI 41_ VSSAL 46_ MIWKG 51_ LIVLT 56_ GSESP 61_ IVVVL 66_ SGSME 71_ PAFHR 76_ GDLLF 81_ LTNFR 86_ EDPIR 91_ AGEIV 96_ VFKVE 101_ GRDIP 106_ IVHRV 111_ IKVHE 116_ KDNGD 121_ IKFLT 126_ KGDNN 131_ EVDDR 136_ GLYKE 141_ GQNWL 146_ EKKDV 151_ VGRAR 156_ GFLPY 161_ VGMVT 166_ IIMND 171_ YPKFK 176_ YALLA 181_ VMGAY 186_VLLKR
1: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369)