Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D)
1_MEPGC 6_ DEFLP 11_ PPECP 16_ VFEPS 21_ WAEFQ 26_ DPLGY 31_ IAKIR 36_ PIAEK 41_ SGICK 46_ IRPPA 51_ DWQPP 56_ FAVEV 61_ DNFRF 66_ TPRVQ 71_ RLNEL 76_ EAQTR 81_ VKLNY 86_ LDQIA 91_ KFWEI 96_ QGSSL 101_ KIPNV 106_ ERKIL 111_ DLYSL 116_ SKIVI 121_ EEGGY 126_ EAICK 131_ DRRWA 136_ RVAQR 141_ LHYPP 146_ GKNIG 151_ SLLRS 156_ HYERI 161_ IYPYE 166_ MFQSG 171_ ANHVQ 176_ CNTHP 181_ FDNEV 186_ KDKEY 191_ KPHSI 196_ PLRQS 201_ VQPSK 206_ FSSYS 211_ RRAKR 216_ LQPDP 221_ EPTEE 226_ DIEKH 231_ PELKK 236_ LQIYG 241_ PGPKM 246_ MGLGL 251_ MAKDK 256_ DKTVH 261_ KKVTC 266_ PPTVT 271_ VKDEQ 276_ SGGGN 281_ VSSTL 286_ LKQHL 291_ SLEPC 296_ TKTTM 301_ QLRKN 306_ HSSAQ 311_ FIDSY 316_ ICQVC 321_ SRGDE 326_ DDKLL 331_ FCDGC 336_ DDNYH 341_ IFCLL 346_ PPLPE 351_ IPRGI 356_ WRCPK 361_ CILAE 366_ CKQPP 371_ EAFGF 376_ EQATQ 381_ EYSLQ 386_ SFGEM 391_ ADSFK 396_ SDYFN 401_ MPVHM 406_ VPTEL 411_ VEKEF 416_ WRLVS 421_ SIEED 426_ VTVEY 431_ GADIH 436_ SKEFG 441_ SGFPV 446_ SNSKQ 451_ NLSPE 456_ EKEYA 461_ TSGWN 466_ LNVMP 471_ VLDQS 476_ VLCHI 481_ NADIS 486_ GMKVP 491_ WLYVG 496_ MVFSA 501_ FCWHI 506_ EDHWS 511_ YSINY 516_ LHWGE 521_ PKTWY 526_ GVPSL 531_ AAEHL 536_ EEVMK 541_ MLTPE 546_ LFDSQ 551_ PDLLH 556_ QLVTL 561_ MNPNT 566_ LMSHG 571_ VPVVR 576_ TNQCA 581_ GEFVI 586_ TFPRA 591_ YHSGF 596_ NQGYN 601_ FAEAV 606_ NFCTA 611_ DWLPA 616_ GRQCI 621_ EHYRR 626_ LRRYC 631_ VFSHE 636_ ELICK 641_ MAAFP 646_ ETLDL 651_ NLAVA 656_ VHKEM 661_ FIMVQ 666_ EERRL 671_ RKALL 676_ EKGVT 681_ EAERE 686_ AFELL 691_ PDDER 696_ QCIKC 701_ KTTCF 706_ LSALA 711_ CYDCP 716_ DGLVC 721_ LSHIN 726_ DLCKC 731_ SSSRQ 736_ YLRYR 741_ YTLDE 746_ LPTML 751_ HKLKI 756_ RAESF 761_ DTWAN 766_ KVRVA 771_ LEVED 776_ GRKRS 781_ FEELR 786_ ALESE 791_ ARERR 796_ FPNSE 801_ LLQRL 806_ KNCLS 811_ EVEAC 816_ IAQVL 821_ GLVSG 826_ QVARM 831_ DTPQL 836_ TLTEL 841_ RVLLE 846_ QMGSL 851_ PCAMH 856_ QIGDV 861_ KDVLE 866_ QVEAY 871_ QAEAR 876_ EALAT 881_ LPSSP 886_ GLLRS 891_ LLERG 896_ QQLGV 901_ EVPEA 906_ HQLQQ 911_ QVEQA 916_ QWLDE 921_ VKQAL 926_ APSAH 931_ RGSLV 936_ IMQGL 941_ LVMGA 946_ KIASS 951_ PSVDK 956_ ARAEL 961_ QELLT 966_ IAERW 971_ EEKAH 976_ FCLEA 981_ RQKHP 986_ PATLE 991_ AIIRE 996_ TENIP 1001_ VHLPN 1006_ IQALK 1011_ EALTK 1016_ AQAWI 1021_ ADVDE 1026_ IQNGD 1031_ HYPCL 1036_ DDLEG 1041_ LVAVG 1046_ RDLPV 1051_ GLEEL 1056_ RQLEL 1061_ QVLTA 1066_ HSWRE 1071_ KASKT 1076_ FLKKN 1081_ SCYTL 1086_ LEVLC 1091_ PCADA 1096_ GSDST 1101_ KRSRW 1106_ MEKAL 1111_ GLYQC 1116_ DTELL 1121_ GLSAQ 1126_ DLRDP 1131_ GSVIV 1136_ AFKEG 1141_ EQKEK 1146_ EGILQ 1151_ LRRTN 1156_ SAKPS 1161_ PLAPS 1166_ LMASS 1171_ PTSIC 1176_ VCGQV 1181_ PAGVG 1186_ VLQCD 1191_ LCQDW 1196_ FHGQC 1201_ VSVPH 1206_ LLTSP 1211_ KPSLT 1216_ SSPLL 1221_ AWWEW 1226_ DTKFL 1231_ CPLCM 1236_ RSRRP 1241_ RLETI 1246_ LALLV 1251_ ALQRL 1256_ PVRLP 1261_ EGEAL 1266_ QCLTE 1271_ RAIGW 1276_ QDRAR 1281_ KALAS 1286_ EDVTA 1291_ LLRQL 1296_ AELRQ 1301_ QLQAK 1306_ PRPEE 1311_ ASVYT 1316_ SATAC 1321_ DPIRE 1326_ GSGNN 1331_ ISKVQ 1336_ GLLEN 1341_ GDSVT 1346_ SPENM 1351_ APGKG 1356_ SDLEL 1361_ LSSLL 1366_ PQLTG 1371_ PVLEL 1376_ PEAIR 1381_ APLEE 1386_ LMMEG 1391_ DLLEV 1396_ TLDEN 1401_ HSIWQ 1406_ LLQAG 1411_ QPPDL 1416_ DRIRT 1421_ LLELE 1426_ KFEHQ 1431_ GSRTR 1436_ SRALE 1441_ RRRRR 1446_ QKVDQ 1451_ GRNVE 1456_ NLVQQ 1461_ ELQSK 1466_ RARSS 1471_ GIMSQ 1476_ VGREE 1481_ EHYQE 1486_ KADRE 1491_ NMFLT 1496_ PSTDH 1501_ SPFLK 1506_ GNQNS 1511_ LQHKD 1516_ SGSSA 1521_ ACPSL 1526_ MPLLQ 1531_LSYSD
1: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks