Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
1_MASVV 6_ LPSGS 11_ QCAAA 16_ AAAAA 21_ PPGLR 26_ LRLLL 31_ LLFSA 36_ AALIP 41_ TGDGQ 46_ NLFTK 51_ DVTVI 56_ EGEVA 61_ TISCQ 66_ VNKSD 71_ DSVIQ 76_ LLNPN 81_ RQTIY 86_ FRDFR 91_ PLKDS 96_ RFQLL 101_ NFSSS 106_ ELKVS 111_ LTNVS 116_ ISDEG 121_ RYFCQ 126_ LYTDP 131_ PQESY 136_ TTITV 141_ LVPPR 146_ NLMID 151_ IQKDT 156_ AVEGE 161_ EIEVN 166_ CTAMA 171_ SKPAT 176_ TIRWF 181_ KGNTE 186_ LKGKS 191_ EVEEW 196_ SDMYT 201_ VTSQL 206_ MLKVH 211_ KEDDG 216_ VPVIC 221_ QVEHP 226_ AVTGN 231_ LQTQR 236_ YLEVQ 241_ YKPQV 246_ HIQMT 251_ YPLQG 256_ LTREG 261_ DALEL 266_ TCEAI 271_ GKPQP 276_ VMVTW 281_ VRVDD 286_ EMPQH 291_ AVLSG 296_ PNLFI 301_ NNLNK 306_ TDNGT 311_ YRCEA 316_ SNIVG 321_ KAHSD 326_ YMLYV 331_ YDPPT 336_ TIPPP 341_ TTTTT 346_ TTTTT 351_ TTTIL 356_ TIITD 361_ SRAGE 366_ EGSIR 371_ AVDHA 376_ VIGGV 381_ VAVVV 386_ FAMLC 391_ LLIIL 396_ GRYFA 401_ RHKGT 406_ YFTHE 411_ AKGAD 416_ DAADA 421_ DTAII 426_ NAEGG 431_ QNNSE 436_EKKEY
1: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12050160, PubMed:22438059). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246)
2: (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus