Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) [Cleaved into: ANGPTL4 N-terminal chain; ANGPTL4 C-terminal chain]
1_MSGAP 6_ TAGAA 11_ LMLCA 16_ ATAVL 21_ LSAQG 26_ GPVQS 31_ KSPRF 36_ ASWDE 41_ MNVLA 46_ HGLLQ 51_ LGQGL 56_ REHAE 61_ RTRSQ 66_ LSALE 71_ RRLSA 76_ CGSAC 81_ QGTEG 86_ STDLP 91_ LAPES 96_ RVDPE 101_ VLHSL 106_ QTQLK 111_ AQNSR 116_ IQQLF 121_ HKVAQ 126_ QQRHL 131_ EKQHL 136_ RIQHL 141_ QSQFG 146_ LLDHK 151_ HLDHE 156_ VAKPA 161_ RRKRL 166_ PEMAQ 171_ PVDPA 176_ HNVSR 181_ LHRLP 186_ RDCQE 191_ LFQVG 196_ ERQSG 201_ LFEIQ 206_ PQGSP 211_ PFLVN 216_ CKMTS 221_ DGGWT 226_ VIQRR 231_ HDGSV 236_ DFNRP 241_ WEAYK 246_ AGFGD 251_ PHGEF 256_ WLGLE 261_ KVHSI 266_ TGDRN 271_ SRLAV 276_ QLRDW 281_ DGNAE 286_ LLQFS 291_ VHLGG 296_ EDTAY 301_ SLQLT 306_ APVAG 311_ QLGAT 316_ TVPPS 321_ GLSVP 326_ FSTWD 331_ QDHDL 336_ RRDKN 341_ CAKSL 346_ SGGWW 351_ FGTCS 356_ HSNLN 361_ GQYFR 366_ SIPQQ 371_ RQKLK 376_ KGIFW 381_ KTWRG 386_ RYYPL 391_ QATTM 396_ LIQPM 401_AAEAA
1: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis (By similarity)
2: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697)