Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)
1_MADIS 6_ LDELI 11_ RKRGA 16_ AAKGR 21_ LNARP 26_ GVGGV 31_ RSRVG 36_ IQQGL 41_ LSQST 46_ RTATF 51_ QQRFD 56_ ARQKI 61_ GLSDA 66_ RLKLG 71_ VKDAR 76_ EKLLQ 81_ KDARF 86_ RIKGK 91_ VQDAR 96_ EMLNS 101_ RKQQT 106_ TVPQK 111_ PRQVA 116_ DAREK 121_ ISLKR 126_ SSPAA 131_ FINPP 136_ IGTVT 141_ PALKL 146_ TKTIQ 151_ VPQQK 156_ AMAPL 161_ HPHPA 166_ GMRIN 171_ VVNNH 176_ QAKQN 181_ LYDLD 186_ EDDDG 191_ IASVP 196_ TKQMK 201_ FAASG 206_ GFLHH 211_ MAGLS 216_ SSKLS 221_ MSKAL 226_ PLTKV 231_ VQNDA 236_ YTAPA 241_ LPSSI 246_ RTKAL 251_ TNMSR 256_ TLVNK 261_ EEPPK 266_ ELPAA 271_ EPVLS 276_ PLEGT 281_ KMTVN 286_ NLHPR 291_ VTEED 296_ IVELF 301_ CVCGA 306_ LKRAR 311_ LVHPG 316_ VAEVV 321_ FVKKD 326_ DAITA 331_ YKKYN 336_ NRCLD 341_ GQPMK 346_ CNLHM 351_ NGNVI 356_ TSDQP 361_ ILLRL 366_ SDSPS 371_ MKKES 376_ ELPRR 381_ VNSAS 386_ SSNPP 391_ AEVDP 396_ DTILK 401_ ALFKS 406_ SGASV 411_ TTQPT 416_EFKIK
1: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex