E3 ubiquitin-protein ligase RNF26 (EC 2.3.2.27) (RING finger protein 26)
1_MEAVY 6_ LVVNG 11_ LGLVL 16_ DVLTL 21_ VLDLN 26_ FLLVS 31_ SLLAS 36_ LAWLL 41_ AFVYN 46_ LPHTV 51_ LTSLL 56_ HLGRG 61_ VLLSL 66_ LALIE 71_ AVVRF 76_ TCGGL 81_ QALCT 86_ LLYSC 91_ CSGLE 96_ SLKLL 101_ GHLAS 106_ HGALR 111_ SREIL 116_ HRGVL 121_ NVVSS 126_ GHALL 131_ RQACD 136_ ICAIA 141_ MSLVA 146_ YVINS 151_ LVNIC 156_ LIGTQ 161_ NLFSL 166_ VLALW 171_ DAVTG 176_ PLWRM 181_ TDVVA 186_ AFLAH 191_ ISSSA 196_ VAMAI 201_ LLWTP 206_ CQLAL 211_ ELLAS 216_ AARLL 221_ ASFVL 226_ VNLTG 231_ LVLLA 236_ CVLAV 241_ TVTVL 246_ HPDFT 251_ LRLAT 256_ QALSQ 261_ LHARP 266_ SYHRL 271_ REDVM 276_ RLSRL 281_ ALGSE 286_ AWRRV 291_ WSRSL 296_ QLASW 301_ PNRGG 306_ APGAP 311_ QGDPM 316_ RVFSV 321_ RTRRQ 326_ DTLPE 331_ AGRRS 336_ EAEEE 341_ EARTI 346_ RVTPV 351_ RGRER 356_ LNEEE 361_ PPGGQ 366_ DPWKL 371_ LKEQE 376_ ERKKC 381_ VICQD 386_ QSKTV 391_ LLLPC 396_ RHLCL 401_ CQACT 406_ EILMR 411_ HPVYH 416_ RNCPL 421_ CRRGI 426_LQTLN
1: E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1 (PubMed:27368102, PubMed:33472082). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379, PubMed:32614325). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379)