SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
1_MDGPG 6_ ASAVV 11_ VRVGI 16_ PDLQQ 21_ TKCLR 26_ LDPAA 31_ PVWAA 36_ KQRVL 41_ CALNH 46_ SLQDA 51_ LNYGL 56_ FQPPS 61_ RGRAG 66_ KFLDE 71_ ERLLQ 76_ EYPPN 81_ LDTPL 86_ PYLEF 91_ RYKRR 96_ VYAQN 101_ LIDDK 106_ QFAKL 111_ HTKAN 116_ LKKFM 121_ DYVQL 126_ HSTDK 131_ VARLL 136_ DKGLD 141_ PNFHD 146_ PDSGE 151_ CPLSL 156_ AAQLD 161_ NATDL 166_ LKVLK 171_ NGGAH 176_ LDFRT 181_ RDGLT 186_ AVHCA 191_ TRQRN 196_ AAALT 201_ TLLDL 206_ GASPD 211_ YKDSR 216_ GLTPL 221_ YHSAL 226_ GGGDA 231_ LCCEL 236_ LLHDH 241_ AQLGI 246_ TDENG 251_ WQEIH 256_ QACRF 261_ GHVQH 266_ LEHLL 271_ FYGAD 276_ MGAQN 281_ ASGNT 286_ ALHIC 291_ ALYNQ 296_ ESCAR 301_ VLLFR 306_ GANRD 311_ VRNYN 316_ SQTAF 321_ QVAII 326_ AGNFE 331_ LAEVI 336_ KTHKD 341_ SDVVP 346_ FRETP 351_ SYAKR 356_ RRLAG 361_ PSGLA 366_ SPRPL 371_ QRSAS 376_ DINLK 381_ GEAQP 386_ AASPG 391_ PSLRS 396_ LPHQL 401_ LLQRL 406_ QEEKD 411_ RDRDA 416_ DQESN 421_ ISGPL 426_ AGRAG 431_ QSKIS 436_ PSGPG 441_ GPGPA 446_ PGPGP 451_ APPAP 456_ PAPPP 461_ RGPKR 466_ KLYSA 471_ VPGRK 476_ FIAVK 481_ AHSPQ 486_ GEGEI 491_ PLHRG 496_ EAVKV 501_ LSIGE 506_ GGFWE 511_ GTVKG 516_ RTGWF 521_ PADCV 526_ EEVQM 531_ RQHDT 536_ RPETR 541_ EDRTK 546_ RLFRH 551_ YTVGS 556_ YDSLT 561_ SHSDY 566_ VIDDK 571_ VAVLQ 576_ KRDHE 581_ GFGFV 586_ LRGAK 591_ AETPI 596_ EEFTP 601_ TPAFP 606_ ALQYL 611_ ESVDV 616_ EGVAW 621_ RAGLR 626_ TGDFL 631_ IEVNG 636_ VNVVK 641_ VGHKQ 646_ VVALI 651_ RQGGN 656_ RLVMK 661_ VVSVT 666_ RKPEE 671_ DGARR 676_ RAPPP 681_ PKRAP 686_ STTLT 691_ LRSKS 696_ MTAEL 701_ EELAS 706_ IRRRK 711_ GEKLD 716_ EMLAA 721_ AAEPT 726_ LRPDI 731_ ADADS 736_ RAATV 741_ KQRPT 746_ SRRIT 751_ PAEIS 756_ SLFER 761_ QGLPG 766_ PEKLP 771_ GSLRK 776_ GIPRT 781_ KSVGE 786_ DEKLA 791_ SLLEG 796_ RFPRS 801_ TSMQD 806_ PVREG 811_ RGIPP 816_ PPQTA 821_ PPPPP 826_ APYYF 831_ DSGPP 836_ PAFSP 841_ PPPPG 846_ RAYDT 851_ VRSSF 856_ KPGLE 861_ ARLGA 866_ GAAGL 871_ YEPGA 876_ ALGPL 881_ PYPER 886_ QKRAR 891_ SMIIL 896_ QDSAP 901_ ESGDA 906_ PRPPP 911_ AATPP 916_ ERPKR 921_ RPRPP 926_ GPDSP 931_ YANLG 936_ AFSAS 941_ LFAPS 946_ KPQRR 951_ KSPLV 956_ KQLQV 961_ EDAQE 966_ RAALA 971_ VGSPG 976_ PGGGS 981_ FAREP 986_ SPTHR 991_ GPRPG 996_ GLDYG 1001_ AGDGP 1006_ GLAFG 1011_ GPGPA 1016_ KDRRL 1021_ EERRR 1026_ STVFL 1031_ SVGAI 1036_ EGSAP 1041_ GADLP 1046_ SLQPS 1051_ RSIDE 1056_ RLLGT 1061_ GPTAG 1066_ RDLLL 1071_ PSPVS 1076_ ALKPL 1081_ VSGPS 1086_ LGPSG 1091_ STFIH 1096_ PLTGK 1101_ PLDPS 1106_ SPLAL 1111_ ALAAR 1116_ ERALA 1121_ SQAPS 1126_ RSPTP 1131_ VHSPD 1136_ ADRPG 1141_ PLFVD 1146_ VQARD 1151_ PERGS 1156_ LASPA 1161_ FSPRS 1166_ PAWIP 1171_ VPARR 1176_ EAEKV 1181_ PREER 1186_ KSPED 1191_ KKSMI 1196_ LSVLD 1201_ TSLQR 1206_ PAGLI 1211_ VVHAT 1216_ SNGQE 1221_ PSRLG 1226_ GAEEE 1231_ RPGTP 1236_ ELAPA 1241_ PMQSA 1246_ AVAEP 1251_ LPSPR 1256_ AQPPG 1261_ GTPAD 1266_ AGPGQ 1271_ GSSEE 1276_ EPELV 1281_ FAVNL 1286_ PPAQL 1291_ SSSDE 1296_ ETREE 1301_ LARIG 1306_ LVPPP 1311_ EEFAN 1316_ GVLLA 1321_ TPLAG 1326_ PGPSP 1331_ TTVPS 1336_ PASGK 1341_ PSSEP 1346_ PPAPE 1351_ SAADS 1356_ GVEEA 1361_ DTRSS 1366_ SDPHL 1371_ ETTST 1376_ ISTVS 1381_ SMSTL 1386_ SSESG 1391_ ELTDT 1396_ HTSFA 1401_ DGHTF 1406_ LLEKP 1411_ PVPPK 1416_ PKLKS 1421_ PLGKG 1426_ PVTFR 1431_ DPLLK 1436_ QSSDS 1441_ ELMAQ 1446_ QHHAA 1451_ SAGLA 1456_ SAAGP 1461_ ARPRY 1466_ LFQRR 1471_ SKLWG 1476_ DPVES 1481_ RGLPG 1486_ PEDDK 1491_ PTVIS 1496_ ELSSR 1501_ LQQLN 1506_ KDTRS 1511_ LGEEP 1516_ VGGLG 1521_ SLLDP 1526_ AKKSP 1531_ IAAAR 1536_ LFSSL 1541_ GELSS 1546_ ISAQR 1551_ SPGGP 1556_ GGGAS 1561_ YSVRP 1566_ SGRYP 1571_ VARRA 1576_ PSPVK 1581_ PASLE 1586_ RVEGL 1591_ GAGAG 1596_ GAGRP 1601_ FGLTP 1606_ PTILK 1611_ SSSLS 1616_ IPHEP 1621_ KEVRF 1626_ VVRSV 1631_ SARSR 1636_ SPSPS 1641_ PLPSP 1646_ ASGPG 1651_ PGAPG 1656_ PRRPF 1661_ QQKPL 1666_ QLWSK 1671_ FDVGD 1676_ WLESI 1681_ HLGEH 1686_ RDRFE 1691_ DHEIE 1696_ GAHLP 1701_ ALTKD 1706_ DFVEL 1711_ GVTRV 1716_ GHRMN 1721_ IERAL 1726_RQLDG
1: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation