Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease)
1_MERDS 6_ HGNAS 11_ PARTP 16_ SAGAS 21_ PAQAS 26_ PAGTP 31_ PGRAS 36_ PAQAS 41_ PAQAS 46_ PAGTP 51_ PGRAS 56_ PAQAS 61_ PAGTP 66_ PGRAS 71_ PGRAS 76_ PAQAS 81_ PAQAS 86_ PARAS 91_ PALAS 96_ LSRSS 101_ SGRSS 106_ SARSA 111_ SVTTS 116_ PTRVY 121_ LVRAT 126_ PVGAV 131_ PIRSS 136_ PARSA 141_ PATRA 146_ TRESP 151_ GTSLP 156_ KFTWR 161_ EGQKQ 166_ LPLIG 171_ CVLLL 176_ IALVV 181_ SLIIL 186_ FQFWQ 191_ GHTGI 196_ RYKEQ 201_ RESCP 206_ KHAVR 211_ CDGVV 216_ DCKLK 221_ SDELG 226_ CVRFD 231_ WDKSL 236_ LKIYS 241_ GSSHQ 246_ WLPIC 251_ SSNWN 256_ DSYSE 261_ KTCQQ 266_ LGFES 271_ AHRTT 276_ EVAHR 281_ DFANS 286_ FSILR 291_ YNSTI 296_ QESLH 301_ RSECP 306_ SQRYI 311_ SLQCS 316_ HCGLR 321_ AMTGR 326_ IVGGA 331_ LASDS 336_ KWPWQ 341_ VSLHF 346_ GTTHI 351_ CGGTL 356_ IDAQW 361_ VLTAA 366_ HCFFV 371_ TREKV 376_ LEGWK 381_ VYAGT 386_ SNLHQ 391_ LPEAA 396_ SIAEI 401_ IINSN 406_ YTDEE 411_ DDYDI 416_ ALMRL 421_ SKPLT 426_ LSAHI 431_ HPACL 436_ PMHGQ 441_ TFSLN 446_ ETCWI 451_ TGFGK 456_ TRETD 461_ DKTSP 466_ FLREV 471_ QVNLI 476_ DFKKC 481_ NDYLV 486_ YDSYL 491_ TPRMM 496_ CAGDL 501_ RGGRD 506_ SCQGD 511_ SGGPL 516_ VCEQN 521_ NRWYL 526_ AGVTS 531_ WGTGC 536_ GQRNK 541_ PGVYT 546_ KVTEV 551_ LPWIY 556_ SKMEV 561_ RSLQQ 566_ DTAPS 571_ RLGTS 576_ SGGDP 581_GGAPR
1: Serine protease (PubMed:20977675, PubMed:28710277, PubMed:34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed:34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed:20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity)