Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
1_MEGVA 6_ VVTAG 11_ SVGAA 16_ KTEGA 21_ AALPP 26_ PPPVS 31_ PPALT 36_ PAPAA 41_ GEEGP 46_ APLSE 51_ TGAPG 56_ CSGSR 61_ PPELE 66_ PERSL 71_ GRFRG 76_ RFEDE 81_ DEELE 86_ EEEEL 91_ EEEEE 96_ EEEED 101_ MSHFS 106_ LRLEG 111_ GRQDS 116_ EDEEE 121_ RLINL 126_ SELTP 131_ YILCS 136_ ICKGY 141_ LIDAT 146_ TITEC 151_ LHTFC 156_ KSCIV 161_ RHFYY 166_ SNRCP 171_ KCNIV 176_ VHQTQ 181_ PLYNI 186_ RLDRQ 191_ LQDIV 196_ YKLVI 201_ NLEER 206_ EKKQM 211_ HDFYK 216_ ERGLE 221_ VPKPA 226_ VPQPV 231_ PSSKG 236_ RSKKV 241_ LESVF 246_ RIPPE 251_ LDMSL 256_ LLEFI 261_ GANEG 266_ TGHFK 271_ PLEKK 276_ FVRVS 281_ GEATI 286_ GHVEK 291_ FLRRK 296_ MGLDP 301_ ACQVD 306_ IICGD 311_ HLLEQ 316_ YQTLR 321_ EIRRA 326_ IGDAA 331_ MQDGL 336_ LVLHY 341_GLVVS
1: Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332)