Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]
1_MSSSS 6_ WLLLS 11_ LVAVT 16_ AAQST 21_ IEEQA 26_ KTFLD 31_ KFNHE 36_ AEDLF 41_ YQSSL 46_ ASWNY 51_ NTNIT 56_ EENVQ 61_ NMNNA 66_ GDKWS 71_ AFLKE 76_ QSTLA 81_ QMYPL 86_ QEIQN 91_ LTVKL 96_ QLQAL 101_ QQNGS 106_ SVLSE 111_ DKSKR 116_ LNTIL 121_ NTMST 126_ IYSTG 131_ KVCNP 136_ DNPQE 141_ CLLLE 146_ PGLNE 151_ IMANS 156_ LDYNE 161_ RLWAW 166_ ESWRS 171_ EVGKQ 176_ LRPLY 181_ EEYVV 186_ LKNEM 191_ ARANH 196_ YEDYG 201_ DYWRG 206_ DYEVN 211_ GVDGY 216_ DYSRG 221_ QLIED 226_ VEHTF 231_ EEIKP 236_ LYEHL 241_ HAYVR 246_ AKLMN 251_ AYPSY 256_ ISPIG 261_ CLPAH 266_ LLGDM 271_ WGRFW 276_ TNLYS 281_ LTVPF 286_ GQKPN 291_ IDVTD 296_ AMVDQ 301_ AWDAQ 306_ RIFKE 311_ AEKFF 316_ VSVGL 321_ PNMTQ 326_ GFWEN 331_ SMLTD 336_ PGNVQ 341_ KAVCH 346_ PTAWD 351_ LGKGD 356_ FRILM 361_ CTKVT 366_ MDDFL 371_ TAHHE 376_ MGHIQ 381_ YDMAY 386_ AAQPF 391_ LLRNG 396_ ANEGF 401_ HEAVG 406_ EIMSL 411_ SAATP 416_ KHLKS 421_ IGLLS 426_ PDFQE 431_ DNETE 436_ INFLL 441_ KQALT 446_ IVGTL 451_ PFTYM 456_ LEKWR 461_ WMVFK 466_ GEIPK 471_ DQWMK 476_ KWWEM 481_ KREIV 486_ GVVEP 491_ VPHDE 496_ TYCDP 501_ ASLFH 506_ VSNDY 511_ SFIRY 516_ YTRTL 521_ YQFQF 526_ QEALC 531_ QAAKH 536_ EGPLH 541_ KCDIS 546_ NSTEA 551_ GQKLF 556_ NMLRL 561_ GKSEP 566_ WTLAL 571_ ENVVG 576_ AKNMN 581_ VRPLL 586_ NYFEP 591_ LFTWL 596_ KDQNK 601_ NSFVG 606_ WSTDW 611_ SPYAD 616_ QSIKV 621_ RISLK 626_ SALGD 631_ KAYEW 636_ NDNEM 641_ YLFRS 646_ SVAYA 651_ MRQYF 656_ LKVKN 661_ QMILF 666_ GEEDV 671_ RVANL 676_ KPRIS 681_ FNFFV 686_ TAPKN 691_ VSDII 696_ PRTEV 701_ EKAIR 706_ MSRSR 711_ INDAF 716_ RLNDN 721_ SLEFL 726_ GIQPT 731_ LGPPN 736_ QPPVS 741_ IWLIV 746_ FGVVM 751_ GVIVV 756_ GIVIL 761_ IFTGI 766_ RDRKK 771_ KNKAR 776_ SGENP 781_ YASID 786_ ISKGE 791_ NNPGF 796_QNTDD
1: Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10924499, PubMed:10969042, PubMed:11815627, PubMed:14504186, PubMed:19021774). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582)
2: (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63
3: Non-functional as a carboxypeptidase
4: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2