Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5)
1_MRMLV 6_ SGRRV 11_ KKWQL 16_ IIQLF 21_ ATCFL 26_ ASLMF 31_ FWEPI 36_ DNHIV 41_ SHMKS 46_ YSYRY 51_ LINSY 56_ DFVND 61_ TLSLK 66_ HTSAG 71_ PRYQY 76_ LINHK 81_ EKCQA 86_ QDVLL 91_ LLFVK 96_ TAPEN 101_ YDRRS 106_ GIRRT 111_ WGNEN 116_ YVRSQ 121_ LNANI 126_ KTLFA 131_ LGTPN 136_ PLEGE 141_ ELQRK 146_ LAWED 151_ QRYND 156_ IIQQD 161_ FVDSF 166_ YNLTL 171_ KLLMQ 176_ FSWAN 181_ TYCPH 186_ AKFLM 191_ TADDD 196_ IFIHM 201_ PNLIE 206_ YLQSL 211_ EQIGV 216_ QDFWI 221_ GRVHR 226_ GAPPI 231_ RDKSS 236_ KYYVS 241_ YEMYQ 246_ WPAYP 251_ DYTAG 256_ AAYVI 261_ SGDVA 266_ AKVYE 271_ ASQTL 276_ NSSLY 281_ IDDVF 286_ MGLCA 291_ NKIGI 296_ VPQDH 301_ VFFSG 306_ EGKTP 311_ YHPCI 316_ YEKMM 321_ TSHGH 326_ LEDLQ 331_ DLWKN 336_ ATDPK 341_ VKTIS 346_ KGFFG 351_ QIYCR 356_ LMKII 361_ LLCKI 366_ SYVDT 371_YPCRA
1: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development