Gasdermin-C (Melanoma-derived leucine zipper-containing extranuclear factor) [Cleaved into: Gasdermin-C, N-terminal (GSDMC-NT); Gasdermin-C, C-terminal (GSDMC-CT)]
1_MPSML 6_ ERISK 11_ NLVKE 16_ IGSKD 21_ LTPVK 26_ YLLSA 31_ TKLRQ 36_ FVILR 41_ KKKDS 46_ RSSFW 51_ EQSDY 56_ VPVEF 61_ SLNDI 66_ LEPSS 71_ SVLET 76_ VVTGP 81_ FHFSD 86_ IMIQK 91_ HKADM 96_ GVNVG 101_ IEVSV 106_ SGEAS 111_ VDHGC 116_ SLEFQ 121_ IVTIP 126_ SPNLE 131_ DFQKR 136_ KLLDP 141_ EPSFL 146_ KECRR 151_ RGDNL 156_ YVVTE 161_ AVELI 166_ NNTVL 171_ YDSSS 176_ VNILG 181_ KIALW 186_ ITYGK 191_ GQGQG 196_ ESLRV 201_ KKKAL 206_ TLQKG 211_ MVMAY 216_ KRKQL 221_ VIKEK 226_ AILIS 231_ DDDEQ 236_ RTFQD 241_ EYEIS 246_ EMVGY 251_ CAARS 256_ EGLLP 261_ SFHTI 266_ SPTLF 271_ NASSN 276_ DMKLK 281_ PELFL 286_ TQQFL 291_ SGHLP 296_ KYEQV 301_ HILPV 306_ GRIEE 311_ PFWQN 316_ FKHLQ 321_ EEVFQ 326_ KIKTL 331_ AQLSK 336_ DVQDV 341_ MFYSI 346_ LAMLR 351_ DRGAL 356_ QDLMN 361_ MLELD 366_ SSGHL 371_ DGPGG 376_ AILKK 381_ LQQDS 386_ NHAWF 391_ NPKDP 396_ ILYLL 401_ EAIMV 406_ LSDFQ 411_ HDLLA 416_ CSMEK 421_ RILLQ 426_ QQELV 431_ RSILE 436_ PNFRY 441_ PWSIP 446_ FTLKP 451_ ELLAP 456_ LQSEG 461_ LAITY 466_ GLLEE 471_ CGLRM 476_ ELDNP 481_ RSTWD 486_ VEAKM 491_ PLSAL 496_ YGTLS 501_LLQQL
1: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis
2: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:27281216, PubMed:32929201, PubMed:34012073). Produced by the cleavage of gasdermin-C by caspase CASP8 in response to death signals (PubMed:32929201, PubMed:34012073). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids (PubMed:32929201, PubMed:34012073). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32929201, PubMed:34012073)