NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL)
1_MIVDK 6_ LLDDS 11_ RGGEG 16_ LRDAA 21_ GGCGL 26_ MTSPL 31_ NLSYF 36_ YGASP 41_ PAAAP 46_ GACDA 51_ SCSVL 56_ GPSAP 61_ GSPGS 66_ DSSDF 71_ SSASS 76_ VSSCG 81_ AVESR 86_ SRGGA 91_ RAERQ 96_ PVEPH 101_ MGVGR 106_ QQRGP 111_ FQGVR 116_ VKNSV 121_ KELLL 126_ HIRSH 131_ KQKAS 136_ GQAVD 141_ DFKTQ 146_ GVNIE 151_ QFREL 156_ KNTVS 161_ YSGKR 166_ KGPDS 171_ LSDGP 176_ ACKRP 181_ ALLHS 186_ QFLTP 191_ PQTPT 196_ PGESM 201_ EDVHL 206_ NEPKQ 211_ ESSAD 216_ LLQNI 221_ INIKN 226_ ECSPV 231_ SLNTV 236_ QVSWL 241_ NPVVV 246_ PQSSP 251_ AEQCQ 256_ DFHGG 261_ QVFSP 266_ PQKCQ 271_ PFQVR 276_ GSQQM 281_ IDQAS 286_ LYQYS 291_ PQNQH 296_ VEQQP 301_ HYTHK 306_ PTLEY 311_ SPFPI 316_ PPQSP 321_ AYEPN 326_ LFDGP 331_ ESQFC 336_ PNQSL 341_ VSLLG 346_ DQRES 351_ ENIAN 356_ PMQTS 361_ SSVQQ 366_ QNDAH 371_ LHSFS 376_ MMPSS 381_ ACEAM 386_ VGHEM 391_ ASDSS 396_ NTSLP 401_ FSNMG 406_ NPMNT 411_ TQLGK 416_ SLFQW 421_ QVEQE 426_ ESKLA 431_ NISQD 436_ QFLSK 441_ DADGD 446_ TFLHI 451_ AVAQG 456_ RRALS 461_ YVLAR 466_ KMNAL 471_ HMLDI 476_ KEHNG 481_ QSAFQ 486_ VAVAA 491_ NQHLI 496_ VQDLV 501_ NIGAQ 506_ VNTTD 511_ CWGRT 516_ PLHVC 521_ AEKGH 526_ SQVLQ 531_ AIQKG 536_ AVGSN 541_ QFVDL 546_ EATNY 551_ DGLTP 556_ LHCAV 561_ IAHNA 566_ VVHEL 571_ QRNQQ 576_ PHSPE 581_ VQELL 586_ LKNKS 591_ LVDTI 596_ KCLIQ 601_ MGAAV 606_ EAKDR 611_ KSGRT 616_ ALHLA 621_ AEEAN 626_ LELIR 631_ LFLEL 636_ PSCLS 641_ FVNAK 646_ AYNGN 651_ TALHV 656_ AASLQ 661_ YRLTQ 666_ LDAVR 671_ LLMRK 676_ GADPS 681_ TRNLE 686_ NEQPV 691_ HLVPD 696_ GPVGE 701_ QIRRI 706_ LKGKS 711_IQQRA
1: Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645). Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645). Also seems to activate NF-kappa-B-mediated transcription (PubMed:16622025). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025). Promotes transcription of LCN2 and DEFB4 (PubMed:16622025). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity)