Hyccin (Down-regulated by CTNNB1 protein A) (Protein FAM126A)
1_MFTSE 6_ KGVVE 11_ EWLSE 16_ FKTLP 21_ ETSLP 26_ NYATN 31_ LKDKS 36_ SLVSS 41_ LYKVI 46_ QEPQS 51_ ELLEP 56_ VCHQL 61_ FEFYR 66_ SGEEQ 71_ LLQFT 76_ LQFLP 81_ ELIWC 86_ YLAVS 91_ ASRNV 96_ HSSGC 101_ IEALL 106_ LGVYN 111_ LEIVD 116_ KQGHT 121_ KVLSF 126_ TIPSL 131_ SKPSV 136_ YHEPS 141_ SIGSM 146_ ALTES 151_ ALSQH 156_ GLSKV 161_ VYSGP 166_ HPQRE 171_ MLTAQ 176_ NRFEV 181_ LTFLL 186_ LCYNA 191_ ALTYM 196_ PSVSL 201_ QSLCQ 206_ ICSRI 211_ CVCGY 216_ PRQHV 221_ RKYKG 226_ ISSRI 231_ PVSSG 236_ FMVQM 241_ LTGIY 246_ FAFYN 251_ GEWDL 256_ AQKAL 261_ DDIIY 266_ RAQLE 271_ LYPEP 276_ LLVAN 281_ AIKAS 286_ LPHGP 291_ MKSNK 296_ EGTRC 301_ IQVEI 306_ TPTSS 311_ RISRN 316_ AVTSM 321_ SIRGH 326_ RWKRH 331_ GNTEL 336_ TGQEE 341_ LMEIS 346_ EVDEG 351_ FYSRA 356_ ASSTS 361_ QSGLS 366_ NSSHN 371_ CSNKP 376_ SIGKN 381_ HRRSG 386_ GSKTG 391_ GKEKE 396_ TTGES 401_ CKDHF 406_ ARKQT 411_ QRAQS 416_ ENLEL 421_ LSLKR 426_ LTLTT 431_ SQSLP 436_ KPSSH 441_ GLAKT 446_ AATVF 451_ SKSFE 456_ QVSGV 461_ TVPHN 466_ PSSAV 471_ GCGAG 476_ TDANR 481_ FSACS 486_ LQEEK 491_ LIYVS 496_ ERTEL 501_ PMKHQ 506_ SGQQR 511_ PPSIS 516_ITLST
1: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable)