Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7)
1_MAVYR 6_ LCVTT 11_ GPYLR 16_ AGTLD 21_ NISVT 26_ LVGTC 31_ GESPK 36_ QRLDR 41_ MGRDF 46_ APGSV 51_ QKYKV 56_ RCTAE 61_ LGELL 66_ LLRVH 71_ KERYA 76_ FFRKD 81_ SWYCS 86_ RICVT 91_ EPDGS 96_ VSHFP 101_ CYQWI 106_ EGYCT 111_ VELRP 116_ GTART 121_ ICQDS 126_ LPLLL 131_ DHRTR 136_ ELRAR 141_ QECYR 146_ WKIYA 151_ PGFPC 156_ MVDVN 161_ SFQEM 166_ ESDKK 171_ FALTK 176_ TTTCV 181_ DQGDS 186_ SGNRY 191_ LPGFP 196_ MKIDI 201_ PSLMY 206_ MEPNV 211_ RYSAT 216_ KTISL 221_ LFNAI 226_ PASLG 231_ MKLRG 236_ LLDRK 241_ GSWKK 246_ LDDMQ 251_ NIFWC 256_ HKTFT 261_ TKYVT 266_ EHWCE 271_ DHFFG 276_ YQYLN 281_ GVNPV 286_ MLHCI 291_ SSLPS 296_ KLPVT 301_ NDMVA 306_ PLLGQ 311_ DTCLQ 316_ TELER 321_ GNIFL 326_ ADYWI 331_ LAEAP 336_ THCLN 341_ GRQQY 346_ VAAPL 351_ CLLWL 356_ SPQGA 361_ LVPLA 366_ IQLSQ 371_ TPGPD 376_ SPIFL 381_ PTDSE 386_ WDWLL 391_ AKTWV 396_ RNSEF 401_ LVHEN 406_ NTHFL 411_ CTHLL 416_ CEAFA 421_ MATLR 426_ QLPLC 431_ HPIYK 436_ LLLPH 441_ TRYTL 446_ QVNTI 451_ ARATL 456_ LNPEG 461_ LVDQV 466_ TSIGR 471_ QGLIY 476_ LMSTG 481_ LAHFT 486_ YTNFC 491_ LPDSL 496_ RARGV 501_ LAIPN 506_ YHYRD 511_ DGLKI 516_ WAAIE 521_ SFVSE 526_ IVGYY 531_ YPSDA 536_ SVQQD 541_ SELQA 546_ WTGEI 551_ FAQAF 556_ LGRES 561_ SGFPS 566_ RLCTP 571_ GEMVK 576_ FLTAI 581_ IFNCS 586_ AQHAA 591_ VNSGQ 596_ HDFGA 601_ WMPNA 606_ PSSMR 611_ QPPPQ 616_ TKGTT 621_ TLKTY 626_ LDTLP 631_ EVNIS 636_ CNNLL 641_ LFWLV 646_ SQEPK 651_ DQRPL 656_ GTYPD 661_ EHFTE 666_ EAPRR 671_ SIAAF 676_ QSRLA 681_ QISRD 686_ IQERN 691_ QGLAL 696_ PYTYL 701_ DPPLI 706_ENSVS
1: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:12881489, PubMed:17045234, PubMed:20921226, PubMed:20923767). The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:12881489, PubMed:17045234, PubMed:20923767). In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides (PubMed:20921226). In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (PubMed:21558561). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity)