Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21)
1_MASKI 6_ LLNVQ 11_ EEVTC 16_ PICLE 21_ LLTEP 26_ LSLDC 31_ GHSLC 36_ RACIT 41_ VSNKE 46_ AVTSM 51_ GGKSS 56_ CPVCG 61_ ISYSF 66_ EHLQA 71_ NQHLA 76_ NIVER 81_ LKEVK 86_ LSPDN 91_ GKKRD 96_ LCDHH 101_ GEKLL 106_ LFCKE 111_ DRKVI 116_ CWLCE 121_ RSQEH 126_ RGHHT 131_ VLTEE 136_ VFKEC 141_ QEKLQ 146_ AVLKR 151_ LKKEE 156_ EEAEK 161_ LEADI 166_ REEKT 171_ SWKYQ 176_ VQTER 181_ QRIQT 186_ EFDQL 191_ RSILN 196_ NEEQR 201_ ELQRL 206_ EEEEK 211_ KTLDK 216_ FAEAE 221_ DELVQ 226_ QKQLV 231_ RELIS 236_ DVECR 241_ SQWST 246_ MELLQ 251_ DMSGI 256_ MKWSE 261_ IWRLK 266_ KPKMV 271_ SKKLK 276_ TVFHA 281_ PDLSR 286_ MLQMF 291_ RELTA 296_ VRCYW 301_ VDVTL 306_ NSVNL 311_ NLNLV 316_ LSEDQ 321_ RQVIS 326_ VPIWP 331_ FQCYN 336_ YGVLG 341_ SQYFS 346_ SGKHY 351_ WEVDV 356_ SKKTA 361_ WILGV 366_ YCRTY 371_ SRHMK 376_ YVVRR 381_ CANRQ 386_ NLYTK 391_ YRPLF 396_ GYWVI 401_ GLQNK 406_ CKYGV 411_ FEESL 416_ SSDPE 421_ VLTLS 426_ MAVPP 431_ CRVGV 436_ FLDYE 441_ AGIVS 446_ FFNVT 451_ SHGSL 456_ IYKFS 461_ KCCFS 466_ QPVYP 471_ YFNPW 476_ NCPAP 481_MTLCP
1: Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853). During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966). In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709). Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507)