Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)
1_MAVWE 6_ AEQLG 11_ GLQRG 16_ DLLTP 21_ PAPDG 26_ DGRTA 31_ PLGQP 36_ PGAQL 41_ YCPAC 46_ LVTCH 51_ SQEAF 56_ ENHCA 61_ SSEHA 66_ QMVAF 71_ DQALP 76_ WEHRS 81_ PPPGL 86_ SKFEL 91_ CPKPD 96_ LCEYG 101_ DACTK 106_ AHSAQ 111_ ELQEW 116_ VRRTQ 121_ AVELR 126_ GQAAW 131_ QDGLV 136_ PYQER 141_ LLAEY 146_ QRSSS 151_ EVLVL 156_ AETLD 161_ GVRVT 166_ CNQPL 171_ MYQAQ 176_ ERKTQ 181_ YSWTF 186_ AVHSE 191_ EPLLH 196_ VALLK 201_ QEPGA 206_ DFSLV 211_ APGLP 216_ PGRLY 221_ ARGER 226_ FRVPS 231_ STADF 236_ QVGVR 241_ VQAAS 246_ FGTFE 251_ QWVVF 256_ DFGRR 261_ PVLLQ 266_ KLGLQ 271_ LGQGR 276_ RPGPC 281_ RNLAL 286_ GHPEE 291_ MERWH 296_ TGNRH 301_ VVPGV 306_ ERTAE 311_ QTALM 316_ AKYKG 321_ PALAL 326_ EFNRS 331_ SVASG 336_ PISPT 341_ NYRQR 346_ MHQFL 351_ YEEEA 356_ AQQQL 361_ VAKLT 366_ LRGQV 371_ FLKTA 376_ LQTPA 381_ LNMLF 386_ APPGA 391_ LYAEV 396_ PVPSS 401_ LMPDT 406_ DQGFL 411_ LGRAV 416_ STALV 421_ APVPA 426_ PDNTV 431_ FEVRL 436_ ERRAS 441_ SEQAL 446_ WLLLP 451_ ARCCL 456_ ALGLQ 461_ PEARL 466_ VLEVQ 471_ FQIDP 476_ MTFRL 481_ WHQAV 486_ DTLPE 491_ EQLVV 496_ PDLPT 501_ CALPR 506_ PWSVP 511_ PLRRG 516_ NRKQE 521_ LAVAL 526_ IAGWG 531_ PGDGR 536_ RVPPL 541_ LIYGP 546_ FGTGK 551_ TYTLA 556_ MASLE 561_ VIRRP 566_ ETKVL 571_ ICTHT 576_ NSAAD 581_ IYIRE 586_ YFHSH 591_ VSGGH 596_ PEATP 601_ LRVMY 606_ TDRPL 611_ SQTDP 616_ VTLQY 621_ CCLTD 626_ DRQAF 631_ RPPTR 636_ AELAR 641_ HRVVV 646_ TTTSQ 651_ ARELR 656_ VPVGF 661_ FSHIL 666_ IDEAA 671_ QMLEC 676_ EALTP 681_ LAYAS 686_ HGTRL 691_ VLAGD 696_ HMQVT 701_ PRLFS 706_ VARAR 711_ AAEHT 716_ LLHRL 721_ FLCYQ 726_ QETHE 731_ VARQS 736_ RLVFH 741_ ENYRC 746_ TDAIV 751_ SFISR 756_ HFYVA 761_ KGNPI 766_ HARGK 771_ VPPHP 776_ RHYPL 781_ MFCHV 786_ AGSPD 791_ RDMSM 796_ ASWLN 801_ LAEIA 806_ QVVEK 811_ VQEAY 816_ NTWPS 821_ CWGGR 826_ EQRCI 831_ CVVSH 836_ GAQVS 841_ ALRQE 846_ LRRRD 851_ LGQVS 856_ VGSFE 861_ ILPGR 866_ QFRVV 871_ VLSTV 876_ HTCQS 881_ LLSPG 886_ ALAPE 891_ FFTDA 896_ RVLNT 901_ VLTRA 906_ QSQLV 911_ VVGDA 916_ VALCS 921_ FGACG 926_ KLWES 931_ FIREC 936_ VERHS 941_ VCPEG 946_ LSMEQ 951_ VEQGV 956_ AQRRR 961_ WPPRG 966_ TQAGA 971_ AGNWE 976_ AAPEP 981_ VGDLA 986_ EEQAA 991_ VVTAM 996_ VKAEP 1001_ GDEAL 1006_ SPASR 1011_ DITAT 1016_ TAQTE 1021_ AAAAP 1026_ AGDAV 1031_ KEDVV 1036_ PGACA 1041_ AGAAA 1046_ AAGVE 1051_ STEAE 1056_ DAEAD 1061_ FWPWD 1066_ GELNA 1071_ DDAIL 1076_ RELLD 1081_ ESQKV 1086_ MVTVG 1091_ EDGLL 1096_ DTVAR 1101_ PESLQ 1106_ QARLY 1111_ ENLPP 1116_ AALRK 1121_ LLHAE 1126_ PERYR 1131_ HCSFV 1136_ PETFE 1141_ RASAI 1146_ PLDDA 1151_ SSGPI 1156_ QVRGR 1161_ LDCGM 1166_ AFAGD 1171_ EVLVQ 1176_ LLSGD 1181_ KAPEG 1186_ RLRGR 1191_ VLGVL 1196_ KRKRH 1201_ ELAFV 1206_ CRMDT 1211_ WDPRI 1216_ MVPIN 1221_ GSVTK 1226_ IFVAE 1231_ LKDPS 1236_ QVPIY 1241_ SLRKG 1246_ RLQRV 1251_ GLERL 1256_ TAEAR 1261_ HSRLF 1266_ WVQIV 1271_ LWRQG 1276_ FYYPL 1281_ GIVRE 1286_ VLPEA 1291_ STWEQ 1296_ GLRIL 1301_ GLEYS 1306_ LRVPP 1311_ SDQAT 1316_ ITKVL 1321_ QKYHT 1326_ ELGRV 1331_ AGRRE 1336_ DCRAF 1341_ LTFTV 1346_ DPQGA 1351_ CNLDD 1356_ ALSVR 1361_ DLGPR 1366_ CEVAV 1371_ HITDV 1376_ ASFVP 1381_ RDGVL 1386_ DVEAR 1391_ RQGAA 1396_ FYAPG 1401_ REPVP 1406_ MLPAS 1411_ LCQDV 1416_ LSLLP 1421_ GRDRL 1426_ AISLF 1431_ LTMEK 1436_ ASGQL 1441_ KSLRF 1446_ APSVV 1451_ QSDRQ 1456_ LSYEE 1461_ AEEVI 1466_ RQHPG 1471_ AGREL 1476_ PARLD 1481_ SVDAC 1486_ VVAAC 1491_ YFSRL 1496_ LRRHR 1501_ LRSDC 1506_ FYEQP 1511_ DEDGT 1516_ LGFRA 1521_ AHIMV 1526_ KEYMI 1531_ QFNRL 1536_ VAEFL 1541_ VGSEC 1546_ TRTVT 1551_ PLRWQ 1556_ PAPRS 1561_ QQLKA 1566_ LCEKH 1571_ GDRVP 1576_ LSLHL 1581_ GHHLH 1586_ GGGGS 1591_ PPDTR 1596_ LHLLA 1601_ SLWKQ 1606_ VQFAA 1611_ RTQDY 1616_ EQMVD 1621_ LVTTD 1626_ DMHPF 1631_ LAPAG 1636_ RDLRK 1641_ ALERS 1646_ AFGRC 1651_ ARGHQ 1656_ QQGGH 1661_ YSLQV 1666_ DWYTW 1671_ ATSPI 1676_ RRYLD 1681_ VVLQR 1686_ QILLA 1691_ LGHGG 1696_ SAYSA 1701_ RDIDG 1706_ LCQAF 1711_ SLQHA 1716_ LAQSY 1721_ QRRAR 1726_ SLHLA 1731_ VQLKA 1736_ QPLDK 1741_ LGFVV 1746_ DVEAG 1751_ SRCFR 1756_ LLFPS 1761_ NRETL 1766_ PDPCP 1771_ VPYGS 1776_ LQLAE 1781_ HPHAL 1786_ AGRPG 1791_ LRLLW 1796_ RRRVY 1801_ SAQGS 1806_ SPPLP 1811_ LPGTV 1816_ PDPHT 1821_ LAVET 1826_ ALWKQ 1831_ LLELV 1836_ ELQRW 1841_ PEAAA 1846_ LIQEK 1851_ GEASQ 1856_ RRELV 1861_ QVQRS 1866_ HCGHF 1871_ LEVAR 1876_ ELGSG 1881_ DTLQV 1886_ QLGTS 1891_ LQHGF 1896_ LVPSP 1901_ QLWTV 1906_ APGFS 1911_ LCLEH 1916_ VERPG 1921_ DCFSG 1926_ RVYRA 1931_ PRDRY 1936_ RDVDE 1941_ YACVW 1946_ EPFCA 1951_ LESAT 1956_ GAVAE 1961_ NDSVT 1966_ LQHLS 1971_ VSWEA 1976_ SRTPQ 1981_ GQLQG 1986_ AFRLE 1991_ AAFLE 1996_ ENCAD 2001_ INFSC 2006_ CYLCI 2011_ RLEGL 2016_ PAPTA 2021_ SPRPG 2026_ PSSLG 2031_ PGLNV 2036_ DPGTY 2041_ TWVAH 2046_ GQTQD 2051_ WDQER 2056_ RADRQ 2061_ EAPRR 2066_ VHLFV 2071_ HHMGM 2076_ EKVPE 2081_ EVLRP 2086_ GTLFT 2091_ VELLP 2096_ KQLPD 2101_ LRKEE 2106_ AVRGL 2111_ EEASP 2116_ LVTSI 2121_ ALGRP 2126_ VPQPL 2131_ CRVIP 2136_ SRFLE 2141_ RQTYN 2146_ IPGGR 2151_ HKLNP 2156_ SQNVA 2161_ VREAL 2166_ EKPFT 2171_ VIQGP 2176_ PGTGK 2181_ TIVGL 2186_ HIVFW 2191_ FHKSN 2196_ QEQVQ 2201_ PGGPP 2206_ RGEKR 2211_ LGGPC 2216_ ILYCG 2221_ PSNKS 2226_ VDVLA 2231_ GLLLR 2236_ RMELK 2241_ PLRVY 2246_ SEQAE 2251_ ASEFP 2256_ VPRVG 2261_ SRKLL 2266_ RKSPR 2271_ EGRPN 2276_ QSLRS 2281_ ITLHH 2286_ RIRQA 2291_ PNPYS 2296_ SEIKA 2301_ FDTRL 2306_ QRGEL 2311_ FSRED 2316_ LVWYK 2321_ KVLWE 2326_ ARKFE 2331_ LDRHE 2336_ VILCT 2341_ CSCAA 2346_ SASLK 2351_ ILDVR 2356_ QILVD 2361_ EAGMA 2366_ TEPET 2371_ LIPLV 2376_ QFPQA 2381_ EKVVL 2386_ LGDHK 2391_ QLRPV 2396_ VKNER 2401_ LQNLG 2406_ LDRSL 2411_ FERYH 2416_ EDAHM 2421_ LDTQY 2426_ RMHEG 2431_ ICAFP 2436_ SVAFY 2441_ KSKLK 2446_ TWQGL 2451_ RRPPS 2456_ VLGHA 2461_ GKESC 2466_ PVIFG 2471_ HVQGH 2476_ ERSLL 2481_ VSTDE 2486_ GNENS 2491_ KANLE 2496_ EVAEV 2501_ VRITK 2506_ QLTLG 2511_ RTVEP 2516_ QDIAV 2521_ LTPYN 2526_ AQASE 2531_ ISKAL 2536_ RREGI 2541_ AGVAV 2546_ SSITK 2551_ SQGSE 2556_ WRYVL 2561_ VSTVR 2566_ TCAKS 2571_ DLDQR 2576_ PTKSW 2581_ LKKFL 2586_ GFVVD 2591_ PNQVN 2596_ VAVTR 2601_ AQEGL 2606_ CLIGD 2611_ HLLLR 2616_ CCPLW 2621_ RSLLD 2626_ FCEAQ 2631_ QTLVP 2636_ AGQVR 2641_VCRRP
1: Can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities (PubMed:37602378). Shows a strong preference for pyrimidine over purine residues for its nuclease activity (PubMed:37602378). Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (PubMed:16239304, PubMed:23525231)