Gene name: SRXN1

Uniprot entry:

Q9BYN0

Protein names:

Sulfiredoxin-1 (EC 1.8.98.2)

Protein sequence:

1_MGLRA 6_ GGTLG 11_ RAGAG 16_ RGAPE 21_ GPGPS 26_ GGAQG 31_ GSIHS 36_ GRIAA 41_ VHNVP 46_ LSVLI 51_ RPLPS 56_ VLDPA 61_ KVQSL 66_ VDTIR 71_ EDPDS 76_ VPPID 81_ VLWIK 86_ GAQGG 91_ DYFYS 96_ FGGCH 101_ RYAAY 106_ QQLQR 111_ ETIPA 116_ KLVQS 121_ TLSDL 126_ RVYLG 131_ASTPD

Protein annotations

Protein functions:

1: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625). Does not act on PRDX5 or PRDX6 (PubMed:15448164, PubMed:15590625). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (PubMed:15448164, PubMed:15590625)