Anoctamin-3 (Transmembrane protein 16C)
1_MVHHS 6_ GSIQS 11_ FKQQK 16_ GMNIS 21_ KSEIT 26_ KETSL 31_ KPSRR 36_ SLPCL 41_ AQSYA 46_ YSKSL 51_ SQSTS 56_ LFQST 61_ ESESQ 66_ APTSI 71_ TLIST 76_ DKAEQ 81_ VNTEE 86_ NKNDS 91_ VLRCS 96_ FADLS 101_ DFCLA 106_ LGKDK 111_ DYTDE 116_ SEHAT 121_ YDRSR 126_ LINDF 131_ VIKDK 136_ SEFKT 141_ KLSKN 146_ DMNYI 151_ ASSGP 156_ LFKDG 161_ KKRID 166_ YILVY 171_ RKTNI 176_ QYDKR 181_ NTFEK 186_ NLRAE 191_ GLMLE 196_ KEPAI 201_ ASPDI 206_ MFIKI 211_ HIPWD 216_ TLCKY 221_ AERLN 226_ IRMPF 231_ RKKCY 236_ YTDGR 241_ SKSMG 246_ RMQTY 251_ FRRIK 256_ NWMAQ 261_ NPMVL 266_ DKSAF 271_ PDLEE 276_ SDCYT 281_ GPFSR 286_ ARIHH 291_ FIINN 296_ KDTFF 301_ SNATR 306_ SRIVY 311_ HMLER 316_ TKYEN 321_ GISKV 326_ GIRKL 331_ INNGS 336_ YIAAF 341_ PPHEG 346_ AYKSS 351_ QPIKT 356_ HGPQN 361_ NRHLL 366_ YERWA 371_ RWGMW 376_ YKHQP 381_ LDLIR 386_ LYFGE 391_ KIGLY 396_ FAWLG 401_ WYTGM 406_ LIPAA 411_ IVGLC 416_ VFFYG 421_ LFTMN 426_ NSQVS 431_ QEICK 436_ ATEVF 441_ MCPLC 446_ DKNCS 451_ LQRLN 456_ DSCIY 461_ AKVTY 466_ LFDNG 471_ GTVFF 476_ AIFMA 481_ IWATV 486_ FLEFW 491_ KRRRS 496_ ILTYT 501_ WDLIE 506_ WEEEE 511_ ETLRP 516_ QFEAK 521_ YYKME 526_ IVNPI 531_ TGKPE 536_ PHQPS 541_ SDKVT 546_ RLLVS 551_ VSGIF 556_ FMISL 561_ VITAV 566_ FGVVV 571_ YRLVV 576_ MEQFA 581_ SFKWN 586_ FIKQY 591_ WQFAT 596_ SAAAV 601_ CINFI 606_ IIMLL 611_ NLAYE 616_ KIAYL 621_ LTNLE 626_ YPRTE 631_ SEWEN 636_ SFALK 641_ MFLFQ 646_ FVNLN 651_ SSIFY 656_ IAFFL 661_ GRFVG 666_ HPGKY 671_ NKLFD 676_ RWRLE 681_ ECHPS 686_ GCLID 691_ LCLQM 696_ GVIMF 701_ LKQIW 706_ NNFME 711_ LGYPL 716_ IQNWW 721_ SRHKI 726_ KRGIH 731_ DASIP 736_ QWEND 741_ WNLQP 746_ MNLHG 751_ LMDEY 756_ LEMVL 761_ QFGFT 766_ TIFVA 771_ AFPLA 776_ PLLAL 781_ LNNII 786_ EIRLD 791_ AYKFV 796_ TQWRR 801_ PLPAR 806_ ATDIG 811_ IWLGI 816_ LEGIG 821_ ILAVI 826_ TNAFV 831_ IAITS 836_ DYIPR 841_ FVYEY 846_ KYGPC 851_ ANHVE 856_ PSENC 861_ LKGYV 866_ NNSLS 871_ FFDLS 876_ ELGMG 881_ KSGYC 886_ RYRDY 891_ RGPPW 896_ SSKPY 901_ EFTLQ 906_ YWHIL 911_ AARLA 916_ FIIVF 921_ EHLVF 926_ GIKSF 931_ IAYLI 936_ PDVPK 941_ GLHDR 946_ IRREK 951_ YLVQE 956_ MMYEA 961_ ELEHL 966_ QQQRR 971_ KSGQP 976_VHHEW
1: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:21984732)