Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (D-AIBAT)
1_MTLIW 6_ RHLLR 11_ PLCLV 16_ TSAPR 21_ ILEMH 26_ PFLSL 31_ GTSRT 36_ SVTKL 41_ SLHTK 46_ PRMPP 51_ CDFMP 56_ ERYQS 61_ LGYNR 66_ VLEIH 71_ KEHLS 76_ PVVTA 81_ YFQKP 86_ LLLHQ 91_ GHMEW 96_ LFDAE 101_ GSRYL 106_ DFFSG 111_ IVTVS 116_ VGHCH 121_ PKVNA 126_ VAQKQ 131_ LGRLW 136_ HTSTV 141_ FFHPP 146_ MHEYA 151_ EKLAA 156_ LLPEP 161_ LKVIF 166_ LVNSG 171_ SEANE 176_ LAMLM 181_ ARAHS 186_ NNIDI 191_ ISFRG 196_ AYHGC 201_ SPYTL 206_ GLTNV 211_ GTYKM 216_ ELPGG 221_ TGCQP 226_ TMCPD 231_ VFRGP 236_ WGGSH 241_ CRDSP 246_ VQTIR 251_ KCSCA 256_ PDCCQ 261_ AKDQY 266_ IEQFK 271_ DTLST 276_ SVAKS 281_ IAGFF 286_ AEPIQ 291_ GVNGV 296_ VQYPK 301_ GFLKE 306_ AFELV 311_ RARGG 316_ VCIAD 321_ EVQTG 326_ FGRLG 331_ SHFWG 336_ FQTHD 341_ VLPDI 346_ VTMAK 351_ GIGNG 356_ FPMAA 361_ VITTP 366_ EIAKS 371_ LAKCL 376_ QHFNT 381_ FGGNP 386_ MACAI 391_ GSAVL 396_ EVIKE 401_ ENLQE 406_ NSQEV 411_ GTYML 416_ LKFAK 421_ LRDEF 426_ EIVGD 431_ VRGKG 436_ LMIGI 441_ EMVQD 446_ KISCR 451_ PLPRE 456_ EVNQI 461_ HEDCK 466_ HMGLL 471_ VGRGS 476_ IFSQT 481_ FRIAP 486_ SMCIT 491_ KPEVD 496_ FAVEV 501_ FRSAL 506_TQHME
1: Multifunctional aminotransferase with a broad substrate specificity (PubMed:20018850, PubMed:23023372, PubMed:24586340). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed:24586340). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (By similarity). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:20018850, PubMed:23023372). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (PubMed:20018850, PubMed:23023372)