Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (RING finger protein 29)
1_MSASL 6_ NYKSF 11_ SKEQQ 16_ TMDNL 21_ EKQLI 26_ CPICL 31_ EMFTK 36_ PVVIL 41_ PCQHN 46_ LCRKC 51_ ASDIF 56_ QASNP 61_ YLPTR 66_ GGTTM 71_ ASGGR 76_ FRCPS 81_ CRHEV 86_ VLDRH 91_ GVYGL 96_ QRNLL 101_ VENII 106_ DIYKQ 111_ ESTRP 116_ EKKSD 121_ QPMCE 126_ EHEEE 131_ RINIY 136_ CLNCE 141_ VPTCS 146_ LCKVF 151_ GAHKD 156_ CQVAP 161_ LTHVF 166_ QRQKS 171_ ELSDG 176_ IAILV 181_ GSNDR 186_ VQGVI 191_ SQLED 196_ TCKTI 201_ EECCR 206_ KQKQE 211_ LCEKF 216_ DYLYG 221_ ILEER 226_ KNEMT 231_ QVITR 236_ TQEEK 241_ LEHVR 246_ ALIKK 251_ YSDHL 256_ ENVSK 261_ LVESG 266_ IQFMD 271_ EPEMA 276_ VFLQN 281_ AKTLL 286_ KKISE 291_ ASKAF 296_ QMEKI 301_ EHGYE 306_ NMNHF 311_ TVNLN 316_ REEKI 321_ IREID 326_ FYRED 331_ EDEEE 336_ EEGGE 341_ GEKEG 346_ EGEVG 351_ GEAVE 356_ VEEVE 361_ NVQTE 366_ FPGED 371_ ENPEK 376_ ASELS 381_ QVELQ 386_ AAPGA 391_ LPVSS 396_ PEPPP 401_ ALPPA 406_ ADAPV 411_ TQGEV 416_ VPTGS 421_ EQTTE 426_ SETPV 431_ PAAAE 436_ TADPL 441_ FYPSW 446_ YKGQT 451_ RKATT 456_ NPPCT 461_ PGSEG 466_ LGQIG 471_ PPGSE 476_ DSNVR 481_ KAEVA 486_ AAAAS 491_ ERAAV 496_ SGKET 501_ SAPAA 506_ TSQIG 511_ FEAPP 516_ LQGQA 521_ AAPAS 526_ GSGAD 531_ SEPAR 536_ HIFSF 541_SWLNS
1: E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression (By similarity). Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Also modifies PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity (PubMed:36737649)