Carotenoid-cleaving dioxygenase, mitochondrial (EC 1.13.11.-) (EC 1.13.11.71) (B-diox-II) (Beta,beta-carotene 9',10'-oxygenase) (Beta-carotene dioxygenase 2)
1_MFFRV 6_ FLHFI 11_ RSHSA 16_ TAVDF 21_ LPVMV 26_ HRLPV 31_ FKRYM 36_ GNTPQ 41_ KKAVF 46_ GQCRG 51_ LPCVA 56_ PLLTT 61_ VEEAP 66_ RGISA 71_ RVWGH 76_ FPKWL 81_ NGSLL 86_ RIGPG 91_ KFEFG 96_ KDKYN 101_ HWFDG 106_ MALLH 111_ QFRMA 116_ KGTVT 121_ YRSKF 126_ LQSDT 131_ YKANS 136_ AKNRI 141_ VISEF 146_ GTLAL 151_ PDPCK 156_ NVFER 161_ FMSRF 166_ ELPGK 171_ AAAMT 176_ DNTNV 181_ NYVRY 186_ KGDYY 191_ LCTET 196_ NFMNK 201_ VDIET 206_ LEKTE 211_ KVDWS 216_ KFIAV 221_ NGATA 226_ HPHYD 231_ LDGTA 236_ YNMGN 241_ SFGPY 246_ GFSYK 251_ VIRVP 256_ PEKVD 261_ LGETI 266_ HGVQV 271_ ICSIA 276_ STEKG 281_ KPSYY 286_ HSFGM 291_ TRNYI 296_ IFIEQ 301_ PLKMN 306_ LWKIA 311_ TSKIR 316_ GKAFS 321_ DGISW 326_ EPQCN 331_ TRFHV 336_ VEKRT 341_ GQLLP 346_ GRYYS 351_ KPFVT 356_ FHQIN 361_ AFEDQ 366_ GCVII 371_ DLCCQ 376_ DNGRT 381_ LEVYQ 386_ LQNLR 391_ KAGEG 396_ LDQVH 401_ NSAAK 406_ SFPRR 411_ FVLPL 416_ NVSLN 421_ APEGD 426_ NLSPL 431_ SYTSA 436_ SAVKQ 441_ ADGTI 446_ WCSHE 451_ NLHQE 456_ DLEKE 461_ GGIEF 466_ PQIYY 471_ DRFSG 476_ KKYHF 481_ FYGCG 486_ FRHLV 491_ GDSLI 496_ KVDVV 501_ NKTLK 506_ VWRED 511_ GFYPS 516_ EPVFV 521_ PAPGT 526_ NEEDG 531_ GVILS 536_ VVITP 541_ NQNES 546_ NFILV 551_ LDAKN 556_ FEELG 561_ RAEVP 566_ VQMPY 571_GFHGT
1: Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules