Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)
1_MKQLQ 6_ PQPPP 11_ KMGDF 16_ YDPEH 21_ PTPEE 26_ EENEA 31_ KIENV 36_ QKTGF 41_ IKGPM 46_ FKGVA 51_ SSRFL 56_ PKGTK 61_ TKVNL 66_ EEQGR 71_ QKVSF 76_ SFSLT 81_ KKTLQ 86_ NRFLT 91_ ALGNE 96_ KQSDT 101_ PNPPA 106_ VPLQV 111_ DSTPK 116_ MKMEI 121_ GDTLS 126_ TAEES 131_ SPPKS 136_ RVELG 141_ KIHFK 146_ KHLLH 151_ VTSRP 156_ LLATT 161_ TAVAS 166_ PPTHA 171_ APLPA 176_ VIAES 181_ TTVDS 186_ PPSSP 191_ PPPPP 196_ PAQAT 201_ TLSSP 206_ APVTE 211_ PVALP 216_ HTPIT 221_ VLMAA 226_ PVPLP 231_ VDVAV 236_ RSLKE 241_ PPIII 246_ VPESL 251_ EADTK 256_ QDTIS 261_ NSLEE 266_ HVTQI 271_ LNEQA 276_ DISSK 281_ KEDSH 286_ IGKDE 291_ EIPDS 296_ SKISL 301_ SCKKT 306_ GSKKK 311_ SSQSE 316_ GIFLG 321_ SESDE 326_ DSVRT 331_ SSSQR 336_ SHDLK 341_ FSASI 346_ EKERD 351_ FKKSS 356_ APLKS 361_ EDLGK 366_ PSRSK 371_ TDRDD 376_ KYFSY 381_ SKLER 386_ DTRYV 391_ SSRCR 396_ SERER 401_ RRSRS 406_ HSRSE 411_ RGSRT 416_ NLSYS 421_ RSERS 426_ HYYDS 431_ DRRYH 436_ RSSPY 441_ RERTR 446_ YSRPY 451_ TDNRA 456_ RESSD 461_ SEEEY 466_ KKTYS 471_ RRTSS 476_ HSSSY 481_ RDLRT 486_ SSYSK 491_ SDRDC 496_ KTETS 501_ YLEME 506_ RRGKY 511_ SSKLE 516_ RESKR 521_ TSENE 526_ AIKRC 531_ CSPPN 536_ ELGFR 541_ RGSSY 546_ SKHDS 551_ SASRY 556_ KSTLS 561_ KPIPK 566_ SDKFK 571_ NSFCC 576_ TELNE 581_ EIKQS 586_ HSFSL 591_ QTPCS 596_ KGSEL 601_ RMINK 606_ NPERE 611_ KAGSP 616_ APSNR 621_ LNDSP 626_ TLKKL 631_ DELPI 636_ FKSEF 641_ ITHDS 646_ HDSIK 651_ ELDSL 656_ SKVKN 661_ DQLRS 666_ FCPIE 671_ LNING 676_ SPGAE 681_ SDLAT 686_ FCTSK 691_ TDAVL 696_ MTSDD 701_ SVTGS 706_ ELSPL 711_ VKACM 716_ LSSNG 721_ FQNIS 726_ RCKEK 731_ DLDDT 736_ CMLHK 741_ KSESP 746_ FRETE 751_ PLVSP 756_ HQDKL 761_ MSMPV 766_ MTVDY 771_ SKTVV 776_ KEPVD 781_ TRVSC 786_ CKTKD 791_ SDIYC 796_ TLNDS 801_ NPSLC 806_ NSEAE 811_ NIEPS 816_ VMKIS 821_ SNSFM 826_ NVHLE 831_ SKPVI 836_ CDSRN 841_ LTDHS 846_ KFACE 851_ EYKQS 856_ IGSTS 861_ SASVN 866_ HFDDL 871_ YQPIG 876_ SSGIA 881_ SSLQS 886_ LPPGI 891_ KVDSL 896_ TLLKC 901_ GENTS 906_ PVLDA 911_ VLKSK 916_ KSSEF 921_ LKHAG 926_ KETIV 931_ EVGSD 936_ LPDSG 941_ KGFAS 946_ RENRR 951_ NNGLS 956_ GKCLQ 961_ EAQEE 966_ GNSIL 971_ PERRG 976_ RPEIS 981_ LDERG 986_ EGGHV 991_ HTSDD 996_ SEVVF 1001_ SSCDL 1006_ NLTME 1011_ DSDGV 1016_ TYALK 1021_ CDSSG 1026_ HAPEI 1031_ VSTVH 1036_ EDYSG 1041_ SSESS 1046_ NDESD 1051_ SEDTD 1056_ SDDSS 1061_ IPRNR 1066_ LQSVV 1071_ VVPKN 1076_ STLPM 1081_ EETSP 1086_ CSSRS 1091_ SQSYR 1096_ HYSDH 1101_ WEDER 1106_ LESRR 1111_ HLYEE 1116_ KFESI 1121_ ASKAC 1126_ PQTDK 1131_ FFLHK 1136_ GTEKN 1141_ PEISF 1146_ TQSSR 1151_ KQIDN 1156_ RLPEL 1161_ SHPQS 1166_ DGVDS 1171_ TSHTD 1176_ VKSDP 1181_ LGHPN 1186_ SEETV 1191_ KAKIP 1196_ SRQQE 1201_ ELPIY 1206_ SSDFE 1211_ DVPNK 1216_ SWQQT 1221_ TFQNR 1226_ PDSRL 1231_ GKTEL 1236_ SFSSS 1241_ CEIPH 1246_ VDGLH 1251_ SSEEL 1256_ RNLGW 1261_ DFSQE 1266_ KPSTT 1271_ YQQPD 1276_ SSYGA 1281_ CGGHK 1286_ YQQNA 1291_ EQYGG 1296_ TRDYW 1301_ QGNGY 1306_ WDPRS 1311_ GRPPG 1316_ TGVVY 1321_ DRTQG 1326_ QVPDS 1331_ LTDDR 1336_ EEEEN 1341_ WDQQD 1346_ GSHFS 1351_ DQSDK 1356_ FLLSL 1361_ QKDKG 1366_ SVQAP 1371_ EISSN 1376_ SIKDT 1381_ LAVNE 1386_ KKDFS 1391_ KNLEK 1396_ NDIKD 1401_ RGPLK 1406_ KRRQE 1411_ IESDS 1416_ ESDGE 1421_ LQDRK 1426_ KVRVE 1431_ VEQGE 1436_ TSVPP 1441_ GSALV 1446_ GPSCV 1451_ MDDFR 1456_ DPQRW 1461_ KECAK 1466_ QGKMP 1471_ CYFDL 1476_ IEENV 1481_ YLTER 1486_ KKNKS 1491_ HRDIK 1496_ RMQCE 1501_ CTPLS 1506_ KDERA 1511_ QGEIA 1516_ CGEDC 1521_ LNRLL 1526_ MIECS 1531_ SRCPN 1536_ GDYCS 1541_ NRRFQ 1546_ RKQHA 1551_ DVEVI 1556_ LTEKK 1561_ GWGLR 1566_ AAKDL 1571_ PSNTF 1576_ VLEYC 1581_ GEVLD 1586_ HKEFK 1591_ ARVKE 1596_ YARNK 1601_ NIHYY 1606_ FMALK 1611_ NDEII 1616_ DATQK 1621_ GNCSR 1626_ FMNHS 1631_ CEPNC 1636_ ETQKW 1641_ TVNGQ 1646_ LRVGF 1651_ FTTKL 1656_ VPSGS 1661_ ELTFD 1666_ YQFQR 1671_ YGKEA 1676_ QKCFC 1681_ GSANC 1686_ RGYLG 1691_ GENRV 1696_ SIRAA 1701_ GGKMK 1706_ KERSR 1711_ KKDSV 1716_ DGELE 1721_ ALMEN 1726_ GEGLS 1731_ DKNQV 1736_ LSLSR 1741_ LMVRI 1746_ ETLEQ 1751_ KLTCL 1756_ ELIQN 1761_ THSQS 1766_ CLKSF 1771_ LERHG 1776_ LSLLW 1781_ IWMAE 1786_ LGDGR 1791_ ESNQK 1796_ LQEEI 1801_ IKTLE 1806_ HLPIP 1811_ TKNML 1816_ EESKV 1821_ LPIIQ 1826_ RWSQT 1831_ KTAVP 1836_ PLSEG 1841_ DGYSS 1846_ ENTSR 1851_ AHTPL 1856_ NTPDP 1861_ STKLS 1866_ TEADT 1871_ DTPKK 1876_ LMFRR 1881_ LKIIS 1886_ ENSMD 1891_ SAISD 1896_ ATSEL 1901_ EGKDG 1906_ KEDLD 1911_ QLENV 1916_ PVEEE 1921_ EELQS 1926_ QQLLP 1931_ QQLPE 1936_ CKVDS 1941_ ETNIE 1946_ ASKLP 1951_ TSEPE 1956_ ADAEI 1961_ EPKES 1966_ NGTKL 1971_ EEPIN 1976_ EETPS 1981_ QDEEE 1986_ GVSDV 1991_ ESERS 1996_ QEQPD 2001_ KTVDI 2006_ SDLAT 2011_ KLLDS 2016_ WKDLK 2021_ EVYRI 2026_ PKKSQ 2031_ TEKEN 2036_ TTTER 2041_ GRDAV 2046_ GFRDQ 2051_ TPAPK 2056_ TPNRS 2061_ RERDP 2066_ DKQTQ 2071_ NKEKR 2076_ KRRSS 2081_ LSPPS 2086_ SAYER 2091_ GTKRP 2096_ DDRYD 2101_ TPTSK 2106_ KKVRI 2111_ KDRNK 2116_ LSTEE 2121_ RRKLF 2126_ EQEVA 2131_ QREAQ 2136_ KQQQQ 2141_ MQNLG 2146_ MTSPL 2151_ PYDSL 2156_ GYNAP 2161_ HHPFA 2166_ GYPPG 2171_ YPMQA 2176_ YVDPS 2181_ NPNAG 2186_ KVLLP 2191_ TPSMD 2196_ PVCSP 2201_ APYDH 2206_ AQPLV 2211_ GHSTE 2216_ PLSAP 2221_ PPVPV 2226_ VPHVA 2231_ APVEV 2236_ SSSQY 2241_ VAQSD 2246_ GVVHQ 2251_ DSSVA 2256_ VLPVP 2261_ APGPV 2266_ QGQNY 2271_ SVWDS 2276_ NQQSV 2281_ SVQQQ 2286_ YSPAQ 2291_ SQATI 2296_ YYQGQ 2301_ TCPTV 2306_ YGVTS 2311_ PYSQT 2316_ TPPIV 2321_ QSYAQ 2326_ PSLQY 2331_ IQGQQ 2336_ IFTAH 2341_ PQGVV 2346_ VQPAA 2351_ AVTTI 2356_ VAPGQ 2361_ PQPLQ 2366_ PSEMV 2371_ VTNNL 2376_ LDLPP 2381_ PSPPK 2386_ PKTIV 2391_ LPPNW 2396_ KTARD 2401_ PEGKI 2406_ YYYHV 2411_ ITRQT 2416_ QWDPP 2421_ TWESP 2426_ GDDAS 2431_ LEHEA 2436_ EMDLG 2441_ TPTYD 2446_ ENPMK 2451_ ASKKP 2456_ KTAEA 2461_ DTSSE 2466_ LAKKS 2471_ KEVFR 2476_ KEMSQ 2481_ FIVQC 2486_ LNPYR 2491_ KPDCK 2496_ VGRIT 2501_ TTEDF 2506_ KHLAR 2511_ KLTHG 2516_ VMNKE 2521_ LKYCK 2526_ NPEDL 2531_ ECNEN 2536_ VKHKT 2541_ KEYIK 2546_ KYMQK 2551_ FGAVY 2556_KPKED
1: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426)
2: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression