Beta-defensin 126 (Beta-defensin 26) (DEFB-26) (Defensin, beta 126) (Epididymal secretory protein 13.2) (ESP13.2) (HBD26)
1_MKSLL 6_ FTLAV 11_ FMLLA 16_ QLVSG 21_ NWYVK 26_ KCLND 31_ VGICK 36_ KKCKP 41_ EEMHV 46_ KNGWA 51_ MCGKQ 56_ RDCCV 61_ PADRR 66_ ANYPV 71_ FCVQT 76_ KTTRI 81_ STVTA 86_ TTATT 91_ TLMMT 96_ TASMS 101_ SMAPT 106_PVSPT
1: Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569)