Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)
1_MSNGY 6_ STDEN 11_ FRYLI 16_ SCFRA 21_ RVKMY 26_ IQVEP 31_ VLDYL 36_ TFLPA 41_ EVKEQ 46_ IQRTV 51_ ATSGN 56_ MQAVE 61_ LLLST 66_ LEKGV 71_ WHLGW 76_ TREFV 81_ EALRR 86_ TGSPL 91_ AARYM 96_ NPELT 101_ DLPSP 106_ SFENA 111_ HDEYL 116_ QLLNL 121_ LQPTL 126_ VDKLL 131_ VRDVL 136_ DKCME 141_ EELLT 146_ IEDRN 151_ RIAAA 156_ ENNGN 161_ ESGVR 166_ ELLKR 171_ IVQKE 176_ NWFSA 181_ FLNVL 186_ RQTGN 191_ NELVQ 196_ ELTGS 201_ DCSES 206_ NAEIE 211_ NLSQV 216_ DGPQV 221_ EEQLL 226_ STTVQ 231_ PNLEK 236_ EVWGM 241_ ENNSS 246_ ESSFA 251_ DSSVV 256_ SESDT 261_ SLAEG 266_ SVSCL 271_ DESLG 276_ HNSNM 281_ GSDSG 286_ TMGSD 291_ SDEEN 296_ VAARA 301_ SPEPE 306_ LQLRP 311_ YQMEV 316_ AQPAL 321_ EGKNI 326_ IICLP 331_ TGSGK 336_ TRVAV 341_ YIAKD 346_ HLDKK 351_ KKASE 356_ PGKVI 361_ VLVNK 366_ VLLVE 371_ QLFRK 376_ EFQPF 381_ LKKWY 386_ RVIGL 391_ SGDTQ 396_ LKISF 401_ PEVVK 406_ SCDII 411_ ISTAQ 416_ ILENS 421_ LLNLE 426_ NGEDA 431_ GVQLS 436_ DFSLI 441_ IIDEC 446_ HHTNK 451_ EAVYN 456_ NIMRH 461_ YLMQK 466_ LKNNR 471_ LKKEN 476_ KPVIP 481_ LPQIL 486_ GLTAS 491_ PGVGG 496_ ATKQA 501_ KAEEH 506_ ILKLC 511_ ANLDA 516_ FTIKT 521_ VKENL 526_ DQLKN 531_ QIQEP 536_ CKKFA 541_ IADAT 546_ REDPF 551_ KEKLL 556_ EIMTR 561_ IQTYC 566_ QMSPM 571_ SDFGT 576_ QPYEQ 581_ WAIQM 586_ EKKAA 591_ KEGNR 596_ KERVC 601_ AEHLR 606_ KYNEA 611_ LQIND 616_ TIRMI 621_ DAYTH 626_ LETFY 631_ NEEKD 636_ KKFAV 641_ IEDDS 646_ DEGGD 651_ DEYCD 656_ GDEDE 661_ DDLKK 666_ PLKLD 671_ ETDRF 676_ LMTLF 681_ FENNK 686_ MLKRL 691_ AENPE 696_ YENEK 701_ LTKLR 706_ NTIME 711_ QYTRT 716_ EESAR 721_ GIIFT 726_ KTRQS 731_ AYALS 736_ QWITE 741_ NEKFA 746_ EVGVK 751_ AHHLI 756_ GAGHS 761_ SEFKP 766_ MTQNE 771_ QKEVI 776_ SKFRT 781_ GKINL 786_ LIATT 791_ VAEEG 796_ LDIKE 801_ CNIVI 806_ RYGLV 811_ TNEIA 816_ MVQAR 821_ GRARA 826_ DESTY 831_ VLVAH 836_ SGSGV 841_ IEHET 846_ VNDFR 851_ EKMMY 856_ KAIHC 861_ VQNMK 866_ PEEYA 871_ HKILE 876_ LQMQS 881_ IMEKK 886_ MKTKR 891_ NIAKH 896_ YKNNP 901_ SLITF 906_ LCKNC 911_ SVLAC 916_ SGEDI 921_ HVIEK 926_ MHHVN 931_ MTPEF 936_ KELYI 941_ VRENK 946_ ALQKK 951_ CADYQ 956_ INGEI 961_ ICKCG 966_ QAWGT 971_ MMVHK 976_ GLDLP 981_ CLKIR 986_ NFVVV 991_ FKNNS 996_ TKKQY 1001_ KKWVE 1006_ LPITF 1011_ PNLDY 1016_SECCL
1: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:28594402, PubMed:32169843, PubMed:33727702). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines