Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)]
1_MRRLG 6_ PFHPR 11_ VHWAA 16_ PPSLS 21_ SGLHR 26_ LLFLR 31_ GTRIP 36_ SSTTL 41_ SPPRH 46_ DSLSL 51_ DGGTV 56_ NPPRV 61_ REPTG 66_ REAFG 71_ PSPAS 76_ SDWLP 81_ ARWRN 86_ GRGGR 91_ PRARL 96_ CSGWT 101_ AAEEA 106_ RRNPT 111_ LGGLL 116_ GRQRL 121_ LLRMG 126_ GGRLG 131_ APMER 136_ HGRAS 141_ ATSVS 146_ SAGEQ 151_ AAGDP 156_ EGRRQ 161_ EPLRR 166_ RASSA 171_ SVPAV 176_ GASAE 181_ GTRRD 186_ RLGSY 191_ SGPTS 196_ VSRQR 201_ VESLR 206_ KKRPL 211_ FPWFG 216_ LDIGG 221_ TLVKL 226_ VYFEP 231_ KDITA 236_ EEEEE 241_ EVESL 246_ KSIRK 251_ YLTSN 256_ VAYGS 261_ TGIRD 266_ VHLEL 271_ KDLTL 276_ CGRKG 281_ NLHFI 286_ RFPTH 291_ DMPAF 296_ IQMGR 301_ DKNFS 306_ SLHTV 311_ FCATG 316_ GGAYK 321_ FEQDF 326_ LTIGD 331_ LQLCK 336_ LDELD 341_ CLIKG 346_ ILYID 351_ SVGFN 356_ GRSQC 361_ YYFEN 366_ PADSE 371_ KCQKL 376_ PFDLK 381_ NPYPL 386_ LLVNI 391_ GSGVS 396_ ILAVY 401_ SKDNY 406_ KRVTG 411_ TSLGG 416_ GTFFG 421_ LCCLL 426_ TGCTT 431_ FEEAL 436_ EMASR 441_ GDSTK 446_ VDKLV 451_ RDIYG 456_ GDYER 461_ FGLPG 466_ WAVAS 471_ SFGNM 476_ MSKEK 481_ REAVS 486_ KEDLA 491_ RATLI 496_ TITNN 501_ IGSIA 506_ RMCAL 511_ NENIN 516_ QVVFV 521_ GNFLR 526_ INTIA 531_ MRLLA 536_ YALDY 541_ WSKGQ 546_ LKALF 551_ SEHEG 556_ YFGAV 561_GALLE
1: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:17825826). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726)
2: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis