FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP)
1_MDGTE 6_ GSAGQ 11_ PGPAE 16_ RSHRS 21_ SVSSV 26_ GARAA 31_ DVLVY 36_ LADDT 41_ VVPLA 46_ VENLP 51_ SLSAH 56_ ELHRA 61_ VREVL 66_ QLPDI 71_ ALDVF 76_ ALWLV 81_ SPLLE 86_ VQLKP 91_ KHQPY 96_ KLGRQ 101_ WPELL 106_ LRFTS 111_ APDDD 116_ VAMDE 121_ PFLQF 126_ RRNVF 131_ FPKRR 136_ ELQIH 141_ DEEVL 146_ RLLYE 151_ EAKGN 156_ VLAAR 161_ YPCDV 166_ EDCEA 171_ LGALV 176_ CRVQL 181_ GPYQP 186_ GRPAA 191_ CDLRE 196_ KLDSF 201_ LPAHL 206_ CKRGQ 211_ SLFAA 216_ LRGRG 221_ ARAGP 226_ GEQGL 231_ LNAYR 236_ QVQEV 241_ SSDGG 246_ CEAAL 251_ GTHYR 256_ AYLLK 261_ CHELP 266_ FYGCA 271_ FFHGE 276_ VDKPA 281_ QGFLH 286_ RGGRK 291_ PVSVA 296_ ISLEG 301_ VHVID 306_ SREKH 311_ VLLGL 316_ RFQEL 321_ SWDHT 326_ SPEEE 331_ EPILW 336_ LEFDG 341_ DSEGT 346_ PVNKL 351_ LKIYS 356_ KQAEL 361_ MSSLI 366_ EYCIE 371_ LSQAA 376_ EPAGP 381_ QDSAT 386_ GSPSD 391_ PSSSL 396_ APVQR 401_ PKLRR 406_ QGSVV 411_ SSRIQ 416_ HLSTI 421_ DYVED 426_ GKGIR 431_ RVKPK 436_ RTTSF 441_ FSRQL 446_ SLGQG 451_ SYTVV 456_QPGDS
1: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019)