Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)
1_MALSL 6_ EEEAG 11_ RIKDC 16_ WDNQE 21_ APALS 26_ TCSNA 31_ NIFRR 36_ INAIL 41_ DNSLD 46_ FSRVC 51_ TTPIN 56_ RGIHD 61_ HLPDF 66_ QDSEE 71_ TVTSR 76_ MLFPT 81_ SAQES 86_ SRGLP 91_ DANDL 96_ CLGLQ 101_ SLSLT 106_ GWDRP 111_ WSTQD 116_ SDSSA 121_ QSSTH 126_ SVLSM 131_ LHNPL 136_ GNVLG 141_ KPPLS 146_ FLPLD 151_ PLGSD 156_ LVDKF 161_ PAPSV 166_ RGSRL 171_ DTRPI 176_ LDSRS 181_ SSPSD 186_ SDTSG 191_ FSSGS 196_ DHLSD 201_ LISSL 206_ RISPP 211_ LPFLS 216_ LSGGG 221_ PRDPL 226_ KMGVG 231_ SRMDQ 236_ EQAAL 241_ AAVTP 246_ SPTSA 251_ SKRWP 256_ GASVW 261_ PSWDL 266_ LEAPK 271_ DPFSI 276_ EREAR 281_ LHRQA 286_ AAVNE 291_ ATCTW 296_ SGQLP 301_ PRNYK 306_ NPIYS 311_ CKVFL 316_ GGVPW 321_ DITEA 326_ GLVNT 331_ FRVFG 336_ SLSVE 341_ WPGKD 346_ GKHPR 351_ CPPKG 356_ NMPKG 361_ YVYLV 366_ FELEK 371_ SVRSL 376_ LQACS 381_ HDPLS 386_ PDGLS 391_ EYYFK 396_ MSSRR 401_ MRCKE 406_ VQVIP 411_ WVLAD 416_ SNFVR 421_ SPSQR 426_ LDPSR 431_ TVFVG 436_ ALHGM 441_ LNAEA 446_ LAAIL 451_ NDLFG 456_ GVVYA 461_ GIDTD 466_ KHKYP 471_ IGSGR 476_ VTFNN 481_ QRSYL 486_ KAVSA 491_ AFVEI 496_ KTTKF 501_ TKKVQ 506_ IDPYL 511_ EDSLC 516_ HICSS 521_ QPGPF 526_ FCRDQ 531_ VCFKY 536_ FCRSC 541_ WHWRH 546_ SMEGL 551_ RHHSP 556_ LMRNQ 561_KNRDS
1: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195)