ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2)
1_MGFLH 6_ QLQLL 11_ LWKNV 16_ TLKRR 21_ SPWVL 26_ AFEIF 31_ IPLVL 36_ FFILL 41_ GLRQK 46_ KPTIS 51_ VKEAF 56_ YTAAP 61_ LTSAG 66_ ILPVM 71_ QSLCP 76_ DGQRD 81_ EFGFL 86_ QYANS 91_ TVTQL 96_ LERLD 101_ RVVEE 106_ GNLFD 111_ PARPS 116_ LGSEL 121_ EALRQ 126_ HLEAL 131_ SAGPG 136_ TSGSH 141_ LDRST 146_ VSSFS 151_ LDSVA 156_ RNPQE 161_ LWRFL 166_ TQNLS 171_ LPNST 176_ AQALL 181_ AARVD 186_ PPEVY 191_ HLLFG 196_ PSSAL 201_ DSQSG 206_ LHKGQ 211_ EPWSR 216_ LGGNP 221_ LFRME 226_ ELLLA 231_ PALLE 236_ QLTCT 241_ PGSGE 246_ LGRIL 251_ TVPES 256_ QKGAL 261_ QGYRD 266_ AVCSG 271_ QAAAR 276_ ARRFS 281_ GLSAE 286_ LRNQL 291_ DVAKV 296_ SQQLG 301_ LDAPN 306_ GSDSS 311_ PQAPP 316_ PRRLQ 321_ ALLGD 326_ LLDAQ 331_ KVLQD 336_ VDVLS 341_ ALALL 346_ LPQGA 351_ CTGRT 356_ PGPPA 361_ SGAGG 366_ AANGT 371_ GAGAV 376_ MGPNA 381_ TAEEG 386_ APSAA 391_ ALATP 396_ DTLQG 401_ QCSAF 406_ VQLWA 411_ GLQPI 416_ LCGNN 421_ RTIEP 426_ EALRR 431_ GNMSS 436_ LGFTS 441_ KEQRN 446_ LGLLV 451_ HLMTS 456_ NPKIL 461_ YAPAG 466_ SEVDR 471_ VILKA 476_ NETFA 481_ FVGNV 486_ THYAQ 491_ VWLNI 496_ SAEIR 501_ SFLEQ 506_ GRLQQ 511_ HLRWL 516_ QQYVA 521_ ELRLH 526_ PEALN 531_ LSLDE 536_ LPPAL 541_ RQDNF 546_ SLPSG 551_ MALLQ 556_ QLDTI 561_ DNAAC 566_ GWIQF 571_ MSKVS 576_ VDIFK 581_ GFPDE 586_ ESIVN 591_ YTLNQ 596_ AYQDN 601_ VTVFA 606_ SVIFQ 611_ TRKDG 616_ SLPPH 621_ VHYKI 626_ RQNSS 631_ FTEKT 636_ NEIRR 641_ AYWRP 646_ GPNTG 651_ GRFYF 656_ LYGFV 661_ WIQDM 666_ MERAI 671_ IDTFV 676_ GHDVV 681_ EPGSY 686_ VQMFP 691_ YPCYT 696_ RDDFL 701_ FVIEH 706_ MMPLC 711_ MVISW 716_ VYSVA 721_ MTIQH 726_ IVAEK 731_ EHRLK 736_ EVMKT 741_ MGLNN 746_ AVHWV 751_ AWFIT 756_ GFVQL 761_ SISVT 766_ ALTAI 771_ LKYGQ 776_ VLMHS 781_ HVVII 786_ WLFLA 791_ VYAVA 796_ TIMFC 801_ FLVSV 806_ LYSKA 811_ KLASA 816_ CGGII 821_ YFLSY 826_ VPYMY 831_ VAIRE 836_ EVAHD 841_ KITAF 846_ EKCIA 851_ SLMST 856_ TAFGL 861_ GSKYF 866_ ALYEV 871_ AGVGI 876_ QWHTF 881_ SQSPV 886_ EGDDF 891_ NLLLA 896_ VTMLM 901_ VDAVV 906_ YGILT 911_ WYIEA 916_ VHPGM 921_ YGLPR 926_ PWYFP 931_ LQKSY 936_ WLGSG 941_ RTEAW 946_ EWSWP 951_ WARTP 956_ RLSVM 961_ EEDQA 966_ CAMES 971_ RRFEE 976_ TRGME 981_ EEPTH 986_ LPLVV 991_ CVDKL 996_ TKVYK 1001_ DDKKL 1006_ ALNKL 1011_ SLNLY 1016_ ENQVV 1021_ SFLGH 1026_ NGAGK 1031_ TTTMS 1036_ ILTGL 1041_ FPPTS 1046_ GSATI 1051_ YGHDI 1056_ RTEMD 1061_ EIRKN 1066_ LGMCP 1071_ QHNVL 1076_ FDRLT 1081_ VEEHL 1086_ WFYSR 1091_ LKSMA 1096_ QEEIR 1101_ REMDK 1106_ MIEDL 1111_ ELSNK 1116_ RHSLV 1121_ QTLSG 1126_ GMKRK 1131_ LSVAI 1136_ AFVGG 1141_ SRAII 1146_ LDEPT 1151_ AGVDP 1156_ YARRA 1161_ IWDLI 1166_ LKYKP 1171_ GRTIL 1176_ LSTHH 1181_ MDEAD 1186_ LLGDR 1191_ IAIIS 1196_ HGKLK 1201_ CCGSP 1206_ LFLKG 1211_ TYGDG 1216_ YRLTL 1221_ VKRPA 1226_ EPGGP 1231_ QEPGL 1236_ ASSPP 1241_ GRAPL 1246_ SSCSE 1251_ LQVSQ 1256_ FIRKH 1261_ VASCL 1266_ LVSDT 1271_ STELS 1276_ YILPS 1281_ EAAKK 1286_ GAFER 1291_ LFQHL 1296_ ERSLD 1301_ ALHLS 1306_ SFGLM 1311_ DTTLE 1316_ EVFLK 1321_ VSEED 1326_ QSLEN 1331_ SEADV 1336_ KESRK 1341_ DVLPG 1346_ AEGPA 1351_ SGEGH 1356_ AGNLA 1361_ RCSEL 1366_ TQSQA 1371_ SLQSA 1376_ SSVGS 1381_ ARGDE 1386_ GAGYT 1391_ DVYGD 1396_ YRPLF 1401_ DNPQD 1406_ PDNVS 1411_ LQEVE 1416_ AEALS 1421_ RVGQG 1426_ SRKLD 1431_ GGWLK 1436_ VRQFH 1441_ GLLVK 1446_ RFHCA 1451_ RRNSK 1456_ ALFSQ 1461_ ILLPA 1466_ FFVCV 1471_ AMTVA 1476_ LSVPE 1481_ IGDLP 1486_ PLVLS 1491_ PSQYH 1496_ NYTQP 1501_ RGNFI 1506_ PYANE 1511_ ERREY 1516_ RLRLS 1521_ PDASP 1526_ QQLVS 1531_ TFRLP 1536_ SGVGA 1541_ TCVLK 1546_ SPANG 1551_ SLGPT 1556_ LNLSS 1561_ GESRL 1566_ LAARF 1571_ FDSMC 1576_ LESFT 1581_ QGLPL 1586_ SNFVP 1591_ PPPSP 1596_ APSDS 1601_ PASPD 1606_ EDLQA 1611_ WNVSL 1616_ PPTAG 1621_ PEMWT 1626_ SAPSL 1631_ PRLVR 1636_ EPVRC 1641_ TCSAQ 1646_ GTGFS 1651_ CPSSV 1656_ GGHPP 1661_ QMRVV 1666_ TGDIL 1671_ TDITG 1676_ HNVSE 1681_ YLLFT 1686_ SDRFR 1691_ LHRYG 1696_ AITFG 1701_ NVLKS 1706_ IPASF 1711_ GTRAP 1716_ PMVRK 1721_ IAVRR 1726_ AAQVF 1731_ YNNKG 1736_ YHSMP 1741_ TYLNS 1746_ LNNAI 1751_ LRANL 1756_ PKSKG 1761_ NPAAY 1766_ GITVT 1771_ NHPMN 1776_ KTSAS 1781_ LSLDY 1786_ LLQGT 1791_ DVVIA 1796_ IFIIV 1801_ AMSFV 1806_ PASFV 1811_ VFLVA 1816_ EKSTK 1821_ AKHLQ 1826_ FVSGC 1831_ NPIIY 1836_ WLANY 1841_ VWDML 1846_ NYLVP 1851_ ATCCV 1856_ IILFV 1861_ FDLPA 1866_ YTSPT 1871_ NFPAV 1876_ LSLFL 1881_ LYGWS 1886_ ITPIM 1891_ YPASF 1896_ WFEVP 1901_ SSAYV 1906_ FLIVI 1911_ NLFIG 1916_ ITATV 1921_ ATFLL 1926_ QLFEH 1931_ DKDLK 1936_ VVNSY 1941_ LKSCF 1946_ LIFPN 1951_ YNLGH 1956_ GLMEM 1961_ AYNEY 1966_ INEYY 1971_ AKIGQ 1976_ FDKMK 1981_ SPFEW 1986_ DIVTR 1991_ GLVAM 1996_ AVEGV 2001_ VGFLL 2006_ TIMCQ 2011_ YNFLR 2016_ RPQRM 2021_ PVSTK 2026_ PVEDD 2031_ VDVAS 2036_ ERQRV 2041_ LRGDA 2046_ DNDMV 2051_ KIENL 2056_ TKVYK 2061_ SRKIG 2066_ RILAV 2071_ DRLCL 2076_ GVRPG 2081_ ECFGL 2086_ LGVNG 2091_ AGKTS 2096_ TFKML 2101_ TGDES 2106_ TTGGE 2111_ AFVNG 2116_ HSVLK 2121_ ELLQV 2126_ QQSLG 2131_ YCPQC 2136_ DALFD 2141_ ELTAR 2146_ EHLQL 2151_ YTRLR 2156_ GISWK 2161_ DEARV 2166_ VKWAL 2171_ EKLEL 2176_ TKYAD 2181_ KPAGT 2186_ YSGGN 2191_ KRKLS 2196_ TAIAL 2201_ IGYPA 2206_ FIFLD 2211_ EPTTG 2216_ MDPKA 2221_ RRFLW 2226_ NLILD 2231_ LIKTG 2236_ RSVVL 2241_ TSHSM 2246_ EECEA 2251_ LCTRL 2256_ AIMVN 2261_ GRLRC 2266_ LGSIQ 2271_ HLKNR 2276_ FGDGY 2281_ MITVR 2286_ TKSSQ 2291_ SVKDV 2296_ VRFFN 2301_ RNFPE 2306_ AMLKE 2311_ RHHTK 2316_ VQYQL 2321_ KSEHI 2326_ SLAQV 2331_ FSKME 2336_ QVSGV 2341_ LGIED 2346_ YSVSQ 2351_ TTLDN 2356_ VFVNF 2361_ AKKQS 2366_ DNLEQ 2371_ QETEP 2376_ PSALQ 2381_ SPLGC 2386_ LLSLL 2391_ RPRSA 2396_ PTELR 2401_ ALVAD 2406_ EPEDL 2411_ DTEDE 2416_ GLISF 2421_ EEERA 2426_QLSFN
1: Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity)