Equilibrative nucleoside transporter 3 (hENT3) (Solute carrier family 29 member 3)
1_MAVVS 6_ EDDFQ 11_ HSSNS 16_ TYRTT 21_ SSSLR 26_ ADQEA 31_ LLEKL 36_ LDRPP 41_ PGLQR 46_ PEDRF 51_ CGTYI 56_ IFFSL 61_ GIGSL 66_ LPWNF 71_ FITAK 76_ EYWMF 81_ KLRNS 86_ SSPAT 91_ GEDPE 96_ GSDIL 101_ NYFES 106_ YLAVA 111_ STVPS 116_ MLCLV 121_ ANFLL 126_ VNRVA 131_ VHIRV 136_ LASLT 141_ VILAI 146_ FMVIT 151_ ALVKV 156_ DTSSW 161_ TRGFF 166_ AVTIV 171_ CMVIL 176_ SGAST 181_ VFSSS 186_ IYGMT 191_ GSFPM 196_ RNSQA 201_ LISGG 206_ AMGGT 211_ VSAVA 216_ SLVDL 221_ AASSD 226_ VRNSA 231_ LAFFL 236_ TATVF 241_ LVLCM 246_ GLYLL 251_ LSRLE 256_ YARYY 261_ MRPVL 266_ AAHVF 271_ SGEEE 276_ LPQDS 281_ LSAPS 286_ VASRF 291_ IDSHT 296_ PPLRP 301_ ILKKT 306_ ASLGF 311_ CVTYV 316_ FFITS 321_ LIYPA 326_ ICTNI 331_ ESLNK 336_ GSGSL 341_ WTTKF 346_ FIPLT 351_ TFLLY 356_ NFADL 361_ CGRQL 366_ TAWIQ 371_ VPGPN 376_ SKALP 381_ GFVLL 386_ RTCLI 391_ PLFVL 396_ CNYQP 401_ RVHLK 406_ TVVFQ 411_ SDVYP 416_ ALLSS 421_ LLGLS 426_ NGYLS 431_ TLALL 436_ YGPKI 441_ VPREL 446_ AEATG 451_ VVMSF 456_ YVCLG 461_ LTLGS 466_ACSTL
1: Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). Functions as a non-electrogenic Na(+)-independent transporter (PubMed:15701636, PubMed:19164483, PubMed:28729424). Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments (PubMed:15701636, PubMed:19164483, PubMed:28729424). Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation (PubMed:28729424). May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids (PubMed:28729424). Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine) (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil) (PubMed:15701636, PubMed:19164483). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine (PubMed:19164483). Capable of transporting ATP (PubMed:19164483). Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers (By similarity)