Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1)
1_METLS 6_ FPRYN 11_ VAEIV 16_ IHIRN 21_ KILTG 26_ ADGKN 31_ LTKND 36_ LYPNP 41_ KPEVL 46_ HMIYM 51_ RALQI 56_ VYGIR 61_ LEHFY 66_ MMPVN 71_ SEVMY 76_ PHLME 81_ GFLPF 86_ SNLVT 91_ HLDSF 96_ LPICR 101_ VNDFE 106_ TADIL 111_ CPKAK 116_ RTSRF 121_ LSGII 126_ NFIHF 131_ REACR 136_ ETYME 141_ FLWQY 146_ KSSAD 151_ KMQQL 156_ NAAHQ 161_ EALMK 166_ LERLD 171_ SVPVE 176_ EQEEF 181_ KQLSD 186_ GIQEL 191_ QQSLN 196_ QDFHQ 201_ KTIVL 206_ QEGNS 211_ QKKSN 216_ ISEKT 221_ KRLNE 226_ LKLSV 231_ VSLKE 236_ IQESL 241_ KTKIV 246_ DSPEK 251_ LKNYK 256_ EKMKD 261_ TVQKL 266_ KNARQ 271_ EVVEK 276_ YEIYG 281_ DSVDC 286_ LPSCQ 291_ LEVQL 296_ YQKKI 301_ QDLSD 306_ NREKL 311_ ASILK 316_ ESLNL 321_ EDQIE 326_ SDESE 331_ LKKLK 336_ TEENS 341_ FKRLM 346_ IVKKE 351_ KLATA 356_ QFKIN 361_ KKHED 366_ VKQYK 371_ RTVIE 376_ DCNKV 381_ QEKRG 386_ AVYER 391_ VTTIN 396_ QEIQK 401_ IKLGI 406_ QQLKD 411_ AAERE 416_ KLKSQ 421_ EIFLN 426_ LKTAL 431_ EKYHD 436_ GIEKA 441_ AEDSY 446_ AKIDE 451_ KTAEL 456_KRKMF
1: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)