Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein)
1_MHSLD 6_ EPLDL 11_ KLSIT 16_ KLRAA 21_ REKRE 26_ RTLGV 31_ VRPRA 36_ LHREL 41_ GLVDD 46_ SPTPG 51_ SPGSP 56_ PSGFL 61_ LNSKF 66_ PEKVE 71_ GRFSA 76_ APLVD 81_ LSLSP 86_ PSGLD 91_ SPNGS 96_ SSLSP 101_ ERQGN 106_ GDLPP 111_ VPSAS 116_ DFQPL 121_ RYLDG 126_ VPSSF 131_ QFFLP 136_ LGSGG 141_ ALHLP 146_ ASSFL 151_ TPPKD 156_ KCLSP 161_ DLPLP 166_ KQLVC 171_ RWAKC 176_ NQLFE 181_ LLQDL 186_ VDHVN 191_ DYHVK 196_ PEKDA 201_ GYCCH 206_ WEGCA 211_ RHGRG 216_ FNARY 221_ KMLIH 226_ IRTHT 231_ NEKPH 236_ RCPTC 241_ SKSFS 246_ RLENL 251_ KIHNR 256_ SHTGE 261_ KPYVC 266_ PYEGC 271_ NKRYS 276_ NSSDR 281_ FKHTR 286_ THYVD 291_ KPYYC 296_ KMPGC 301_ HKRYT 306_ DPSSL 311_ RKHIK 316_ AHGHF 321_ VSHEQ 326_ QELLQ 331_ LRPPP 336_ KPPLP 341_ APDGG 346_ PYVSG 351_ AQIII 356_ PNPAA 361_ LFGGP 366_ GLPGL 371_ PLPLA 376_ PGPLD 381_ LSALA 386_ CGNGG 391_ GSGGG 396_ GGMGP 401_ GLPGP 406_ VLPLN 411_ LAKNP 416_ LLPSP 421_ FGAGG 426_ LGLPV 431_ VSLLA 436_ GAAGG 441_ KAEGE 446_ KGRGS 451_ VPTRA 456_ LGMEG 461_ HKTPL 466_ ERTES 471_ SCSRP 476_ SPDGL 481_ PLLPG 486_ TVLDL 491_ STGVN 496_ SAASS 501_ PEALA 506_ PGWVV 511_ IPPGS 516_VLLKP
1: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity)