Uveal autoantigen with coiled-coil domains and ankyrin repeats
1_MKSLK 6_ SRLRR 11_ QDVPG 16_ PASSG 21_ AAAAS 26_ AHAAD 31_ WNKYD 36_ DRLMK 41_ AAERG 46_ DVEKV 51_ TSILA 56_ KKGVN 61_ PGKLD 66_ VEGRS 71_ VFHVV 76_ TSKGN 81_ LECLN 86_ AILIH 91_ GVDIT 96_ TSDTA 101_ GRNAL 106_ HLAAK 111_ YGHAL 116_ CLQKL 121_ LQYNC 126_ PTEHA 131_ DLQGR 136_ TALHD 141_ AAMAD 146_ CPSSI 151_ QLLCD 156_ HGASV 161_ NAKDV 166_ DGRTP 171_ LVLAT 176_ QMSRP 181_ TICQL 186_ LIDRG 191_ ADVNS 196_ RDKQN 201_ RTALM 206_ LGCEY 211_ GCRDA 216_ VEVLI 221_ KNGAD 226_ ISLLD 231_ ALGHD 236_ SSYYA 241_ RIGDN 246_ LDILT 251_ LLKTA 256_ SENTN 261_ KGREL 266_ WKKGP 271_ SLQQR 276_ NLTHM 281_ QDEVN 286_ VKSHQ 291_ REHQN 296_ IQDLE 301_ IENED 306_ LKERL 311_ RKIQQ 316_ EQRIL 321_ LDKVN 326_ GLQLQ 331_ LNEEV 336_ MVADD 341_ LESER 346_ EKLKS 351_ LLAAK 356_ EKQHE 361_ ESLRT 366_ IEALK 371_ NRFKY 376_ FESDH 381_ LGSGS 386_ HFSNR 391_ KEDML 396_ LKQGQ 401_ MYMAD 406_ SQCTS 411_ PGIPA 416_ HMQSR 421_ SMLRP 426_ LELSL 431_ PSQTS 436_ YSENE 441_ ILKKE 446_ LEAMR 451_ TFCES 456_ AKQDR 461_ LKLQN 466_ ELAHK 471_ VAECK 476_ ALALE 481_ CERVK 486_ EDSDE 491_ QIKQL 496_ EDALK 501_ DVQKR 506_ MYESE 511_ GKVKQ 516_ MQTHF 521_ LALKE 526_ HLTSE 531_ AASGN 536_ HRLTE 541_ ELKDQ 546_ LKDLK 551_ VKYEG 556_ ASAEV 561_ GKLRN 566_ QIKQN 571_ EMIVE 576_ EFKRD 581_ EGKLI 586_ EENKR 591_ LQKEL 596_ SMCEM 601_ EREKK 606_ GRKVT 611_ EMEGQ 616_ AKELS 621_ AKLAL 626_ SIPAE 631_ KFENM 636_ KSSLS 641_ NEVNE 646_ KAKKL 651_ VEMER 656_ EHEKS 661_ LSEIR 666_ QLKRE 671_ LENVK 676_ AKLAQ 681_ HVKPE 686_ EHEQV 691_ KSRLE 696_ QKSGE 701_ LGKKI 706_ TELTL 711_ KNQTL 716_ QKEIE 721_ KVYLD 726_ NKLLK 731_ EQAHN 736_ LTIEM 741_ KNHYV 746_ PLKVS 751_ EDMKK 756_ SHDAI 761_ IDDLN 766_ RKLLD 771_ VTQKY 776_ TEKKL 781_ EMEKL 786_ LLEND 791_ SLSKD 796_ VSRLE 801_ TVFVP 806_ PEKHE 811_ KEIIA 816_ LKSNI 821_ VELKK 826_ QLSEL 831_ KKKCG 836_ EDQEK 841_ IHALT 846_ SENTN 851_ LKKMM 856_ SNQYV 861_ PVKTH 866_ EEVKM 871_ TLNDT 876_ LAKTN 881_ RELLD 886_ VKKKF 891_ EDINQ 896_ EFVKI 901_ KDKNE 906_ ILKRN 911_ LENTQ 916_ NQIKA 921_ EYISL 926_ AEHEA 931_ KMSSL 936_ SQSMR 941_ KVQDS 946_ NAEIL 951_ ANYRK 956_ GQEEI 961_ VTLHA 966_ EIKAQ 971_ KKELD 976_ TIQEC 981_ IKVKY 986_ APIVS 991_ FEECE 996_ RKFKA 1001_ TEKEL 1006_ KDQLS 1011_ EQTQK 1016_ YSVSE 1021_ EEVKK 1026_ NKQEN 1031_ DKLKK 1036_ EIFTL 1041_ QKDLR 1046_ DKTVL 1051_ IEKSH 1056_ EMERA 1061_ LSRKT 1066_ DELNK 1071_ QLKDL 1076_ SQKYT 1081_ EVKNV 1086_ KEKLV 1091_ EENAK 1096_ QTSEI 1101_ LAVQN 1106_ LLQKQ 1111_ HVPLE 1116_ QVEAL 1121_ KKSLN 1126_ GTIEN 1131_ LKEEL 1136_ KSMQR 1141_ CYEKE 1146_ QQTVT 1151_ KLHQL 1156_ LENQK 1161_ NSSVP 1166_ LAEHL 1171_ QIKEA 1176_ FEKEV 1181_ GIIKA 1186_ SLREK 1191_ EEESQ 1196_ NKMEE 1201_ VSKLQ 1206_ SEVQN 1211_ TKQAL 1216_ KKLET 1221_ REVVD 1226_ LSKYK 1231_ ATKSD 1236_ LETQI 1241_ SSLNE 1246_ KLANL 1251_ NRKYE 1256_ EVCEE 1261_ VLHAK 1266_ KKEIS 1271_ AKDEK 1276_ ELLHF 1281_ SIEQE 1286_ IKDQK 1291_ ERCDK 1296_ SLTTI 1301_ TELQR 1306_ RIQES 1311_ AKQIE 1316_ AKDNK 1321_ ITELL 1326_ NDVER 1331_ LKQAL 1336_ NGLSQ 1341_ LTYTS 1346_ GNPTK 1351_ RQSQL 1356_ IDTLQ 1361_ HQVKS 1366_ LEQQL 1371_ ADADR 1376_ QHQEV 1381_ IAIYR 1386_ THLLS 1391_ AAQGH 1396_ MDEDV 1401_ QEALL 1406_ QIIQM 1411_RQGLV
1: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity)
2: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity)