Ras-related protein Rab-34 (Ras-related protein Rab-39) (Ras-related protein Rah)
1_MNILA 6_ PVRRD 11_ RVLAE 16_ LPQCL 21_ RKEAA 26_ LHGHK 31_ DFHPR 36_ VTCAC 41_ QEHRT 46_ GTVGF 51_ KISKV 56_ IVVGD 61_ LSVGK 66_ TCLIN 71_ RFCKD 76_ TFDKN 81_ YKATI 86_ GVDFE 91_ MERFE 96_ VLGIP 101_ FSLQL 106_ WDTAG 111_ QERFK 116_ CIAST 121_ YYRGA 126_ QAIII 131_ VFNLN 136_ DVASL 141_ EHTKQ 146_ WLADA 151_ LKEND 156_ PSSVL 161_ LFLVG 166_ SKKDL 171_ STPAQ 176_ YALME 181_ KDALQ 186_ VAQEM 191_ KAEYW 196_ AVSSL 201_ TGENV 206_ REFFF 211_ RVAAL 216_ TFEAN 221_ VLAEL 226_ EKSGA 231_ RRIGD 236_ VVRIN 241_ SDDSN 246_ LYLTA 251_SKKKP
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB34 transports protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:27113757). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Involved in ciliogenesis (PubMed:37384395). In particular, it is required for early steps of the intracellular cilium assembly pathway initiated by trafficking and docking of ciliary vesicles to the centrioles in the cytoplasm, followed by axoneme formation in the cytoplasm. After axoneme elongation, the centrioles migrate close to the cell surface so that ciliary vesicles can fuse with the plasma membrane to expose cilia to the extracellular space (By similarity). It seems dispensable for ciliogenesis via the extracellular pathway where cilium assembly begins after migration and docking of the centriole to the plasma membrane (By similarity). Also acts as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity)