2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)
1_MRRQV 6_ MAALV 11_ VSGAA 16_ EQGGR 21_ DGPGR 26_ GRAPR 31_ GRVAN 36_ QIPPE 41_ ILKNP 46_ QLQAA 51_ IRVLP 56_ SNYNF 61_ EIPKT 66_ IWRIQ 71_ QAQAK 76_ KVALQ 81_ MPEGL 86_ LLFAC 91_ TIVDI 96_ LERFT 101_ EAEVM 106_ VMGDV 111_ TYGAC 116_ CVDDF 121_ TARAL 126_ GADFL 131_ VHYGH 136_ SCLIP 141_ MDTSA 146_ QDFRV 151_ LYVFV 156_ DIRID 161_ TTHLL 166_ DSLRL 171_ TFPPA 176_ TALAL 181_ VSTIQ 186_ FVSTL 191_ QAAAQ 196_ ELKAE 201_ YRVSV 206_ PQCKP 211_ LSPGE 216_ ILGCT 221_ SPRLS 226_ KEVEA 231_ VVYLG 236_ DGRFH 241_ LESVM 246_ IANPN 251_ VPAYR 256_ YDPYS 261_ KVLSR 266_ EHYDH 271_ QRMQA 276_ ARQEA 281_ IATAR 286_ SAKSW 291_ GLILG 296_ TLGRQ 301_ GSPKI 306_ LEHLE 311_ SRLRA 316_ LGLSF 321_ VRLLL 326_ SEIFP 331_ SKLSL 336_ LPEVD 341_ VWVQV 346_ ACPRL 351_ SIDWG 356_ TAFPK 361_ PLLTP 366_ YEAAV 371_ ALRDI 376_ SWQQP 381_ YPMDF 386_ YAGSS 391_ LGPWT 396_ VNHGQ 401_ DRRPH 406_ APGRP 411_ ARGKV 416_ QEGSA 421_ RPPSA 426_ VACED 431_ CSCRD 436_EKVAP
1: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:30877278). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor (PubMed:10519411)