Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X)
1_MKEEK 6_ EHRPK 11_ EKRVT 16_ LLTPA 21_ GATGS 26_ GGGTS 31_ GDSSK 36_ GEDKQ 41_ DRNKE 46_ KKEAL 51_ SKVVI 56_ RRLPP 61_ TLTKE 66_ QLQEH 71_ LQPMP 76_ EHDYF 81_ EFFSN 86_ DTSLY 91_ PHMYA 96_ RAYIN 101_ FKNQE 106_ DIILF 111_ RDRFD 116_ GYVFL 121_ DNKGQ 126_ EYPAI 131_ VEFAP 136_ FQKAA 141_ KKKTK 146_ KRDTK 151_ VGTID 156_ DDPEY 161_ RKFLE 166_ SYATD 171_ NEKMT 176_ STPET 181_ LLEEI 186_ EAKNR 191_ ELIAK 196_ KTTPL 201_ LSFLK 206_ NKQRM 211_ REEKR 216_ EERRR 221_ REIER 226_ KRQRE 231_ EERRK 236_ WKEEE 241_ KRKRK 246_ DIEKL 251_ KKIDR 256_ IPERD 261_ KLKDE 266_ PKIKV 271_ HRFLL 276_ QAVNQ 281_ KNLLK 286_ KPEKG 291_ DEKEL 296_ DKREK 301_ AKKLD 306_ KENLS 311_ DERAS 316_ GQSCT 321_ LPKRS 326_ DSELK 331_ DEKPK 336_ RPEDE 341_ SGRDY 346_ RERER 351_ EYERD 356_ QERIL 361_ RERER 366_ LKRQE 371_ EERRR 376_ QKERY 381_ EKEKT 386_ FKRKE 391_ EEMKK 396_ EKDTL 401_ RDKGK 406_ KAEST 411_ ESIGS 416_ SEKTE 421_ KKEEV 426_ VKRDR 431_ IRNKD 436_ RPAMQ 441_ LYQPG 446_ ARSRN 451_ RLCPP 456_ DDSTK 461_ SGDSA 466_ AERKQ 471_ ESGIS 476_HRKEG
1: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core