G-protein coupled receptor 62 (G-protein coupled receptor GPCR8) (hGPCR8) (G-protein coupled receptor KPG_005)
1_MANST 6_ GLNAS 11_ EVAGS 16_ LGLIL 21_ AAVVE 26_ VGALL 31_ GNGAL 36_ LVVVL 41_ RTPGL 46_ RDALY 51_ LAHLC 56_ VVDLL 61_ AAASI 66_ MPLGL 71_ LAAPP 76_ PGLGR 81_ VRLGP 86_ APCRA 91_ ARFLS 96_ AALLP 101_ ACTLG 106_ VAALG 111_ LARYR 116_ LIVHP 121_ LRPGS 126_ RPPPV 131_ LVLTA 136_ VWAAA 141_ GLLGA 146_ LSLLG 151_ TPPAP 156_ PPAPA 161_ RCSVL 166_ AGGLG 171_ PFRPL 176_ WALLA 181_ FALPA 186_ LLLLG 191_ AYGGI 196_ FVVAR 201_ RAALR 206_ PPRPA 211_ RGSRL 216_ HSDSL 221_ DSRLS 226_ ILPPL 231_ RPRLP 236_ GGKAA 241_ LAPAL 246_ AVGQF 251_ AACWL 256_ PYGCA 261_ CLAPA 266_ ARAAE 271_ AEAAV 276_ TWVAY 281_ SAFAA 286_ HPFLY 291_ GLLQR 296_ PVRLA 301_ LGRLS 306_ RRALP 311_ GPVRA 316_ CTPQA 321_ WHPRA 326_ LLQCL 331_ QRPPE 336_ GPAVG 341_ PSEAP 346_ EQTPE 351_ LAGGR 356_ SPAYQ 361_GPPES
1: Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538)