F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)
1_MSISS 6_ DEVNF 11_ LVYRY 16_ LQESG 21_ FSHSA 26_ FTFGI 31_ ESHIS 36_ QSNIN 41_ GALVP 46_ PAALI 51_ SIIQK 56_ GLQYV 61_ EAEVS 66_ INEDG 71_ TLFDG 76_ RPIES 81_ LSLID 86_ AVMPD 91_ VVQTR 96_ QQAYR 101_ DKLAQ 106_ QQAAA 111_ AAAAA 116_ AAASQ 121_ QGSAK 126_ NGENT 131_ ANGEE 136_ NGAHT 141_ IANNH 146_ TDMME 151_ VDGDV 156_ EIPPN 161_ KAVVL 166_ RGHES 171_ EVFIC 176_ AWNPV 181_ SDLLA 186_ SGSGD 191_ STARI 196_ WNLSE 201_ NSTSG 206_ STQLV 211_ LRHCI 216_ REGGQ 221_ DVPSN 226_ KDVTS 231_ LDWNS 236_ EGTLL 241_ ATGSY 246_ DGFAR 251_ IWTKD 256_ GNLAS 261_ TLGQH 266_ KGPIF 271_ ALKWN 276_ KKGNF 281_ ILSAG 286_ VDKTT 291_ IIWDA 296_ HTGEA 301_ KQQFP 306_ FHSAP 311_ ALDVD 316_ WQSNN 321_ TFASC 326_ STDMC 331_ IHVCK 336_ LGQDR 341_ PIKTF 346_ QGHTN 351_ EVNAI 356_ KWDPT 361_ GNLLA 366_ SCSDD 371_ MTLKI 376_ WSMKQ 381_ DNCVH 386_ DLQAH 391_ NKEIY 396_ TIKWS 401_ PTGPG 406_ TNNPN 411_ ANLML 416_ ASASF 421_ DSTVR 426_ LWDVD 431_ RGICI 436_ HTLTK 441_ HQEPV 446_ YSVAF 451_ SPDGR 456_ YLASG 461_ SFDKC 466_ VHIWN 471_ TQTGA 476_ LVHSY 481_ RGTGG 486_ IFEVC 491_ WNAAG 496_ DKVGA 501_ SASDG 506_SVCVL
1: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation